Jun/Fos, a crucial factor in transmitting the tumor-promoting signal from the extracellular environment to the nuclear transcription machinery, has a dimerization interface possessing several coiled structural properties. Jun and Fos can interact with the DNA regulatory region, AP-1 (Activator Protein-1), which is composed of 5'-TGAC/GTCA-3'. Curcumin is a well-known anticancer and anti-inflamm...

Curcumin and its natural congeners are of current interest because of their putative anti-inflammatory and anticarcinogenic activities, but knowledge about their metabolic fate is scant. In the present study conducted with precision-cut liver slices from male and female Sprague-Dawley rats, five reductive but no oxidative metabolites of curcumin and its demethoxy and bis-demethoxy analogues wer...

ABSTRACT: The relative absorption of a standardized curcuminoid mixture and its corresponding lecithin* formulation (Meriva) was investigated in a randomized, double-blind, cross-over human study. Clinically validated dosages were used for both products, and plasma levels of all three major curcuminoids (curcumin), demethoxycurcumin, and bisdemethoxycurcumin were evaluated. Total curcuminoid ab...

Curcuminoids are vital constituent of turmeric, with therapeutic potential in the treatment of Alzheimer's disease. Electrically, stimulus train-elicited plastic changes in hippocampal CA1 excitability were used as an experimental paradigm to study the effects of curcuminoid mixture and individual components on functional failure induced by Aβ peptide in vitro. Electrical stimulation was applie...

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant antitumor agents, were combined nanoemulsion, using Pluronic F127 a stabilizer.
 METHODS: The main objective is to investigate its cytotoxic activity against cancer cells.
 RESULTS AND DISCUSSION: nanoemulsion show values of particle size (251.4 ± 4.6 nm), zeta potential (-34.8 1.0 mV), pH (4.8) class...

BACKGROUND The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and the metabolite tetrahydrocurcumin after oral administration of three diff...

Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. The limited triumph in the drug development against ALR2 is mainly because of its close structural similarity with the other members of aldo-keto reductase (AKR) superfamily viz. ALR1, AKR1B10; and lipophilicity problem i.e. poor diffusion of synthetic aldose reductase inhibitors (AR...

Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinoma (HepG2) and pancreatic cancer cell line (PANC-1). Based on the highest anti-proliferative activity nine drug candidates were further tested and p...

Background: More than 85% of young people around the world suffer from acne vulgaris, which is most prevalent chronic inflammatory skin illness. The study’s objective was to develop a herbal patch formulation contained quercetin, curcuminoids, and berberine HCl for treatment that utilizing ethyl cellulose HPMC K4M as polymers propylene glycol plasticizer. Materials Methods: Drug excipient compa...

Curcuminoids, the bioactive compounds with many beneficial effects on human health, exist in Curcuma longa (turmeric). In present study, impact of different cell disintegration techniques to enhance total curcuminoid recovery (TC) from fresh and dried turmeric was investigated. The thermal pretreatment (TP), ultrasound (UP), enzyme (EP), pulsed electric field (PEF) curcumin (CUR), demethoxycurc...