نتایج جستجو برای: ctp
تعداد نتایج: 2149 فیلتر نتایج به سال:
Ivacaftor is currently used for the treatment of cystic fibrosis as both monotherapy (Kalydeco; Vertex Pharmaceuticals, Boston, MA) and combination therapy with lumacaftor (Orkambi; Vertex Pharmaceuticals). Each therapy targets specific patient populations: Kalydeco treats patients carrying one of nine gating mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, w...
BACKGROUND AND PURPOSE Recent studies have recommended both early and late imaging to increase spot sign detection. However optimal acquisition timing for spot detection and impact on outcome prediction is uncertain. Our aim was to assess the utility of CTP in spot sign detection and characterization with emphasis on its impact on the prediction of outcome in patients with acute primary ICH. ...
ابرها با توجه به تأثیر قابل توجه آنها بر موازنه‌ی انرژی در سطح زمین و در جو، همواره مورد توجه پژوهشگران مختلف هواشناسی و اقلیمشناسی قرار گرفته است. توانایی سنجش از دور در برآورد خصوصیات و ویژگیهای ابرها در بررسی تغییرات آنها در مکانها و زمانهای مختلف به اثبات رسیده است. یکی از جنبههای تحقیقاتی مهم در ارتباط با ابرها، تعیین فشار در سطح بالای آنها است که هدف از پژوهش حاضر نیز ارائه‌ی رو...
CT Perfusion in Acute Stroke: Added Value or Waste of Time? To the Editor: We read with interest the 2 recent articles by Zhu et al regarding the usefulness of computed tomography perfusion (CTP) studies for predicting outcomes in acute stroke patients. We are puzzled by the analysis of data from the same group of patients being interpreted in such diametrically opposite ways by the same author...
BACKGROUND AND PURPOSE In recent years, the role of CTA and CTP for vasospasm diagnosis in the setting of ASAH has been the subject of many research studies. The purpose of this study was to perform a meta-analysis of the diagnostic performance of CTA and CTP for vasospasm in patients with ASAH by using DSA as the criterion standard. MATERIALS AND METHODS The search strategy for research stud...
BACKGROUND Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype 1 or 4 and advanced liver disease. METHODS We did an open-label study at 34 sites in Europe, Canada, Australia, and New Zealand. Cohort A included patients with Child-Tu...
Our previous work has shown that incubation of K562 cells or lym phocytes from patients with advanced chronic lymphocytic leukemia (CLL) with arabinosyl-2-fluoroadenine (F-ara-A) potentiates the rate of arabinosylcytosine S'-triphosphate (ara-CTP) synthesis during subse quent treatment with arabinosylcytosine (ara-C). To test the biochemical modulation of ara-CTP in a clinical setting, we desig...
PURPOSE The purpose of this study was to investigate the utility incremental diagnostic value of combined assessment with coronary CT angiography (CCTA) and myocardial CT perfusion imaging (CTP) using dual-energy technology with an Adenosine Triphosphate (ATP) load technique. MATERIALS AND METHODS Twenty-one patients underwent ATP-provocation dual-energy CT and CAG. We compared the diagnostic...
lhe integration of chlorophyll a/b-binding (LHCP) polypeptides and the translocation of the 33-kD oxygen-evolving enhancer protein (OEE33) have been previously shown to occur in chloroplast extracts containing stroma, thylakoids, ATP, and MgCI,. We have re-examined the nucleotide requirement for these two reactions using stromal extract and translation products depleted of low molecular weight ...
The purpose of this qualitative study is to elucidate stakeholder perceptions of, and institutional practices related to cell-based therapies and products (CTP) regulation and commercialization in Canada. The development of reproducible, safe and effective CTPs is predicated on regulatory and commercialization environments that enable innovation. Manufacturing processes constitute a critical st...
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