Cryptic splice sites are used only when use of a natural splice site is disrupted by mutation. To determine the features that distinguish authentic from cryptic 5' splice sites (5'ss), we systematically analyzed a set of 76 cryptic 5'ss derived from 46 human genes. These cryptic 5'ss have a similar frequency distribution in exons and introns, and are usually located close to the authentic 5'ss....

Thermal rearrangement of propargyl naphthyl ethers produced naphthopyrans. In the presence of sodium methoxide, propargyl naphthyl ethers were converted easily to naphthofurans and naphthodifurans in good yields

erythrocytes, hematopoietic progenitors, and definitive HSCs are generated sequentially from the same cohort of multipotent founder cells that are laid down almost immediately after mesoderm formation. Developing within the embryo, these founder cells acquire properties of definitive HSCs that may include expression of homing receptor(s), high proliferative potential, etc. Another possible scen...

Submit Manuscript | http://medcraveonline.com Abbreviations: ACTG1: Actin Gamma 1; ARHGDIA: Rho-GDP Dissociation Inhibitor Alpha; BDMR: Brachydactyly-Mental Retardation Syndrome; CMS: Chromosomal Microarray; CNV: Copy Number Variant; FISH: Fluorescence in situ Hybridization; FSCN2: Fascin Actin-Bundling Protein 2, Retinal; TWIST2: Twist-related Protein 2; HDAC4: Histone Deacetylase 4; GPC1: Gly...

Rearrangement of propargyl amine salt, in the presence of a base was studied and it was concluded that this occurs through an allenic intermediate.

This paper describes an attempt to generate seemingly meaningful cryptic crossword clues without trying to analyse meaning but relying solely on word occurrence statistics. It is a continuation of a project in which I developed an application toolkit for cryptic crossword clue compilers. The software described here assembles simple cryptic clues using the resources developed in the earlier proj...

V-D-J rearrangement of the TCR-beta chain follows the 12/23 rule and the beyond 12/23 restriction. Currently, the proportion and characteristics of TCR-beta chain V-J rearrangement is unclear. We used high-throughput sequencing to compare and analyze TCR-beta chain V-J rearrangement and V-D-J rearrangement in the CDR3 repertoires of T cells from the PBMCs of six volunteers and six BALB/c mice. ...

A new member of the genus Deltapartitivirus was identified containing three dsRNAs with an estimated size of 1.71, 1.49 and 1.43 kb. The dsRNAs were extracted from symptomless pigeonpea [Cajanus cajan (L.) Millspaugh] plants cv. Erra Kandulu. This new virus with 4.64 kb genome was tentatively named Arhar cryptic virus-1 (ArCV-1). The genomic RNAs were amplified and characterized by sequence ind...