BACKGROUND Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclos...

In addition to their role in the thrombotic manifestations of the antiphospholipid syndrome (APS), autoimmune antiphospholipid (aPL) antibodies may also be responsible for direct injury to the blood vessel wall, although the mechanism is unclear. Cryoglobulinemia has been reported infrequently in patients with APS and is one potential means of blood vessel injury. The aim of the present study w...

A 48 years male presented with acute axonal neuropathy and palpable purpura over bilateral lower limb, RA factor, and cryoglobulins were present in the serum. Nerve biopsy revealed myelinated fibre loss, axonal degeneration and necrotizing vasculitis of epineural vessels.

Introduction. Several viruses including hepatitis C virus (HCV) and human immunodeficiency (HIV) can induce vasculitis. Aim. We aimed to study the incidence, risk factors, severity of skin vasculitis in patients with HCV HCV/HIV coinfection. Patients Methods. T he group included 331 (254 77 coinfection) referred a specialized hepatology center for antiviral therapy infection. Results. Skin was ...

The frequent association of chronic hepatitic C virus (HCV) infection and type II mixed cryoglobulinemia is considered to be one of the possible signs of interaction between the virus and the immune system. This could also be the case for the appearance of anti-GOR antibodies in serum, as they react with both viral and host antigens. We studied a group of patients with chronic hepatitis C infec...

A patient with cryoglobulinaemia who developed systemic lupus erythematosus (SLE) 10 years later on is described. The relationship between these 2 conditions and the possibility that cryoglobulinaemia was the early presentation of SLE are discussed.