Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...

Differential scanning calorimetry (DSC) is an analytical procedure used to determine the differences in the heat flow generated or absorbed by the sample. This method allows to assess purity and polymorphic form of drug compounds, to detect interactions between ingredients of solid dosage forms and to analyze stability of solid formulations. The aim of this study was the assessment of compatibi...

In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orodispersible tablets by using croscarmelloe sodiu...

The objective of the present work was to optimize the formulation of fast disintegrating tablets (FDTs) of ondansetron HCl containing novel superdisintegrants, possessing sufficient mechanical strength and disintegration time comparable to those containing crospovidone or croscarmellose sodium. The FDTs were formulated using a novel superdisintegrant (chitosan-alginate (1:1) interpolymer comple...

The polyherbal decoction, Gulugulutitakam is known for the treatment of various inflammatory conditions. For the ease of administration, this dosage form has been converted into tablets containing high amount of dry extract but it has the disadvantage of longer disintegration and dissolution parameters. In our attempt to develop tablets with improved disintegration and dissolution time, we have...

An attempt has been made for the development of Orodispersible tablet of Etoricoxib by direct compression method.Sodium starch glycolate, Crospovidone, Croscarmellose, and Ludiflashwere used as a Superdisintegrants for the formulation. Twenty formulation having Superdisintegrants at different concentration (3, 6, 9, 12 %) level were prepared using microcrystalline cellulose as a direct compress...

The purpose of the present study was to formulate and evaluate Berberine HCl Film coated tablet. Preformulation studies API were done. film tablets have advantages over conventional oral dosage forms, tablet also influences release drug after compression. coating help in making with good taste masking properties excellent mechanical strength. It revealed that cellulosic materials unable resist ...

Background: Modafinil is a CNS stimulant used to treat Narcolepsy, sleepiness and other disorders related sleep. It BCS class II drug having poor aqueous solubility.
 Objective: This study was aimed formulate evaluate orodispersible tablets of containing co-crystals for the improvisation critical attributes product such as dissolution rates, solubility oral bioavailability.
 Methods: ...

Abstract Background Cilnidipine, a calcium channel blocker, is the first-line drug for hypertension and belongs to Biopharmaceutics Classification System II. To mitigate its extensive first-pass metabolism improve patient compliance, present study was performed develop characterize solid dispersion-based orodispersible tablets. Results The phase solubility with polyvinyl pyrrolidone 15% has sho...

Aim: This work aims to develop oral disintegrating tablets from solid dispersion of aripiprazole that are capable enhancing solubility.
 Methodology: Aripiprazole an antipsychotic is a BCS class IV drug with Oral bioavailability 87%. To enhance the solubility this dispersions were prepared by using combination ?-Cyclodextrin and PVP K30 in 1:1, 1:2 physical mixture solvent evaporation meth...