objective: the present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of crocus sativus l. (saffron) using mice in two different regimens of acute and sub-acute administration. material and methods: in acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

this study was designed to investigate the therapeutic effects of saffron (crocus sativus l) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (cci) in rats. adult male wistar rats (200 to 250 g) were randomly assigned into 5 groups: sham + saline, cci + saline, cci+ saffron (30 mg/kg), cci +crocin (15 mg/kg) and cci + crocin (30 mg/...

One of the world’s main causes cancer-related fatalities worldwide is colorectal cancer. The adherent epithelial cells known as HCT116 (human carcinoma) are frequently employed to examine inflammatory responses in colonic cells. They derived from human cancer cell line. Crocin, a potent antioxidant, anticarcinogenic was tested this study see how it affected HCT-116 MTT analysis used assess viab...

Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. Methods: In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat di...

Antidepressant activity of crocin, saffron main component, has been established before. Based on previous study, it is suggested that elevation in the levels of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the r...

Introduction: Obesity is known as a multifactorial physical disorder. On the other hand, regular sport exercises and crocin consumption have beneficial effects on obesity. In this regard, the present study aimed to investigate the effect of eight weeks of swimming training with crocin consumption on neurotrophic factors in the heart tissue of obese rats. Methods</strong...

objective(s): crocin, as the main carotenoid of saffron, has shown anti-tumor activity both in vitro and in vivo. crocin might interact with cellular proteins and modulate their functions, but the exact target of this carotenoid and the other compounds of the saffron have not been discovered yet. microtubular proteins, as one of the most important proteins inside the cells, have several functio...

Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is known for its antioxidant activity. Liver as the organ that metabolizes many chemicals is one of the first position that is at risk of environmental pollutants. It is clear that compounds that exhibit antioxidant properties, scavenging of free radicals and inhibition of lipid peroxidation are expected ...

Objective(s) Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was set up using di-gentiobiosyl crocin or a-crocin from Iranian saffron. The...

objective(s) anti-helicobacter pylori effects of saffron (crocus sativus l., iridacea) and its major constituents, crocin and safranal, were evaluated. materials and methods macerated aqueous and methanol extracts tested against 45 clinical isolates of helicobacter pylori, using paper disc diffusion method (ddm) on modified egg yolk emulsion agar (eye agar). four antibiotics also tested against...