Bipolar disorder (BD) is a chronic and burdensome psychiatric disease, characterized by variations in mood energy. The literature has consistently demonstrated an association between BD childhood maltreatment (CM), genetic variants of circadian genes have been associated with increased vulnerability to develop BD. In this context, environmental factors such as CM may also contribute the suscept...

Validation study of the Turkish version of the Craving Typology Questionnaire (CTQ) in male alcohol-dependent patients Objective: Alcohol craving is considered a core symptom of alcohol use disorder and a strong predictor of relapse in alcohol-dependent adults. The Craving Typology Questionnaire (CTQ) allows dimensional selfrating assessment of craving according to a three-pathway psychobiologi...

AIM The aim of this study is to examine whether there is an association between cumulative life adversities and treatment-resistant schizophrenia. METHODS We recruited 186 participants diagnosed with schizophrenia spectrum disorders. Adverse life-events were assessed using the Stressful Life Events Screening Questionnaire (SLESQ) and the Childhood Trauma Questionnaire (CTQ). Treatment resista...

The substances responsible for saffron’s characteristic quality are crocins, picrocrocin, and safranal. The drying process is critical to the saffron quality as measured by levels of secondary metabolites, crocin (color and anti-tumor properties), picrocrocin (taste), and safranal (aroma). Four different dehydration methods were evaluated: Iranian traditional method (room temperature); dehy...

Continuous improvement is the prime requirement for all industries to sustain and grow in competitive global market. This paper a case study of manufacturing industry Taiwan, facing problem rejection brushless motor product. The DMAIC (Define, Measure, Analyze, Improve, Control) cycle was used improve processes reduce rate. In Define phase, anything related processes, products, suppliers, custo...

PURPOSE To develop a reliable and valid quality of life questionnaire for Indian patients with diabetes. METHODS A draft of 75 questions was prepared on the basis of expert opinion, focus group discussions, review of existing literature and detailed semi-structured interviews of patients with diabetes with the intention of including all aspects of diabetes-specific and quality of life conside...

OBJECTIVES The pathogenesis of anxiety is assumed to be interactively influenced by genetic and environmental factors. Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. METHODS A sample of 475 healthy ...