Corticotropin-releasing factor (CRF) orchestrates the mammalian endocrine, autonomic, and behavioral stress response and has been implicated in the pathophysiology of illnesses ranging from irritable bowel syndrome to mood and anxiety disorders. CRF is produced and released from a variety of cell types, making it difficult to distinguish the specific role of CRF from other neurotransmitters wit...

In this paper, we propose a variety of Long Short-Term Memory (LSTM) based models for sequence tagging. These models include LSTM networks, bidirectional LSTM (BI-LSTM) networks, LSTM with a Conditional Random Field (CRF) layer (LSTM-CRF) and bidirectional LSTM with a CRF layer (BI-LSTM-CRF). Our work is the first to apply a bidirectional LSTM CRF (denoted as BI-LSTM-CRF) model to NLP benchmark...

purpose : to evaluate corneal visco-elasticity and intraocular pressure (iop) changes measured by an ocular response analyzer (ora) after scleral buckling methods : fifty-six eyes with history of scleral buckling surgery three months ago were included in the study. corneal hysteresis (ch), corneal resistance factor (crf), corneal-compensated iop (iopcc) and goldmann-correlated iop (iopg) were m...

The interplay of environmental and genetic factors in the developmental organization of the hippocampus has not been fully elucidated. The neuropeptide corticotropin-releasing factor (CRF) is released from hippocampal interneurons by environmental signals, including stress, to increase synaptic efficacy. In the early postnatal hippocampus, we have previously characterized a transient population...

Corticotropin-releasing factor (CRF) and the closely related family of neuropeptides urocortins (Ucns) are ancient paracrine-signaling peptides secreted in both the central and peripheral neural circuits. CRF and Ucns released from the CNS (central) regulate a plethora of physiological processes that include food intake, inflammation, and bowel motility and permeability. In the gastrointestinal...

BACKGROUND Cardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs-cTnT) are associated with risk of all-cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF would be inversely associated with hs-cTnT measured in healthy adults over age 50. METHODS AND RE...

background endothelial injury is a well-known complication in chronic kidney disease (ckd) and hemodialysis. one of the sites in which early vascular changes may be detected is the retina. of course, these flow changes may not be detected in ophthalmologic exams, but it seems that color doppler sonography of retinal arteries may be helpful in these cases. objectives in previous studies on ckd p...

Summary Chronic renal failure (CRF) syndrome significantly alters patients’ quality of life. Anaemia, hypertension, and cardiovascular diseases are common complications CRF. The study aimed to determine the incidence arterial hypertension (AH), anaemia, left ventricular hypertrophy (LVH) in patients with CRF analyze relationship between them. included 212 CRF, treated at Clinic Nephrology Dialy...

Although there is considerable information regarding the role of brain CRF in energy balance, relatively little is known about the role of urocortin (UCN), which is an equally potent anorexic agent. Therefore, the effects of intracerebroventricular (icv) administration of UCN (0.01-1 nmol/day) on food intake and body weight were assessed over a period of 13 days and compared with data from CRF-...

Barrington's nucleus, in the pons, regulates micturition through spinal projections to preganglionic parasympathetic neurons. The stress neuropeptide CRF is prominent in these projections and has an inhibitory influence. Social stress in rats causes urinary retention and abnormal urodynamics resembling those produced by partial bladder outlet obstruction (pBOO), and this is associated with CRF ...