The drug of choice for the treatment of occasional acute symptoms of asthma is an inhaled beta adrenergic agonist, such as salbutamol. The most frequent adverse reactions to salbutamol include nervousness, headache, tremor, tiredness and light-headedness [1]. The following report describes a patient with asthma from childhood, who developed creatine phosphokinase elevation associated with sever...

Studies of the three human creatine phosphokinase (EC 2.7.3.2) isoenzymes, MM, MB, and BB, show that important differences exist in substrate dependency of the reaction rates. A method was developed to study these properties in which the ATP formed in the reverse reaction was measured by means of firefly luciferase. With substrate conditions at which the isoenzymes showed substantial difference...

OBJECTIVE The impact of obesity on ventricular remodeling after myocardial infarction (MI) is still poorly understood. Therefore, the aim of this study was to evaluate the role of waist circumference (WC) and body mass index as predictors of cardiac remodeling in patients after an anterior MI. METHODS Eighty-three consecutive patients with anterior MI were prospectively evaluated. Clinical ch...

Beginning on day 4 ex ovo, and every 3 d thereafter, genetically dystrophic Line 413 chickens were given intraperitoneal injections (4 mg/kg body wt) of a protease inhibitor, leupeptin, pepstatin, or antipain. Experimental chickens received protease inhibitors dissolved in a water:ethanol:dimethyl sulfoxide solution (50:40:10, vol:vol:vol). Control untreated animals received diluent injections....

Background: Hypotonia is a frequent neurological manifestation with numerous etiologies, but recognizing the cause challenge. First, it's necessary to differentiate hypotonia as peripheral, central or mixed. Signs of are normo/hyperreflexia, developmental delay, cognitive delay and/or epileptic seizures associated and normal creatine phosphokinase (CPK). After ruling out environmental risk fact...

2. Dawson DM, Fine IH. Creatine kinase in human tissue. Arch Neurol 1966;16:175-80. 3. Van Der Veen KJ, Willebrands AF. Isoenzyme of creatune phosphokunasein tissue extract and in normal and pathologic sera. Clin Chim Acts 1966;13:312-5. 4. Wagner GS, Roe CR, Liinbird LF, et al. The importanceof identificationof myocardiac specific isoenzyme of creatune phosphokinase (MB form) in the diagnosis ...

The effects of phosphate depletion (PD) of 4, 8, and 12 weeks on skeletal muscle energy metabolism were studied in rats fed a phosphate deficiency diet and compared with rats pairfed with a normal phosphate diet. Skeletal muscle biopsy specimens were examined for energy production, transport, and utilization. The results show that already by 4 weeks of PD, the concentration of inorganic phospho...

Treatment of rat heart mitochondria with phosphate or mersalyl releases a number of proteins, including the mitochondrial creatine kinase (mt-CK). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the released proteins showed that phosphate is more selective than mersalyl in releasing mt-CK. The rebinding of mt-CK to mitochondria was selectively inhibited by adriamycin, which complex...