This descriptive study shows the development and evaluation of a model of social competence in young adolescents with craniofacial anomalies. Craniofacial patients (N = 48, 11-14 years) completed the Social Anxiety Scale for Children, selected subscales of the Self-Perception Scale for Adolescents and the Social Support Scale for Children. Their parents completed the Child Behaviour Checklist. ...

Head morphogenesis requires complex signal relays to enable precisely coordinated proliferation, migration, and patterning. Here, we demonstrate that, during mouse head formation, taspase1-mediated (TASP1-mediated) cleavage of the general transcription factor TFIIA ensures proper coordination of rapid cell proliferation and morphogenesis by maintaining limited transcription of the negative cell...

Toluene embryopathy is characterised by microcephaly, central nervous system dysfunction, attentional deficits and hyperactivity, developmental delay with greater language deficits, minor craniofacial and limb anomalies, and variable growth deficiency. Previously, three affected children, born to women who inhaled toluene regularly throughout pregnancy, have been reported. Two more cases are de...

The use of suxamethonium in our case was uneventful and despite craniofacial anomalies, airway management was straightforward. This case illustrates that pediatric patients with trisomy 18, presenting with potentially acute life-threatening conditions and requiring emergency major surgery can be managed successfully with a multidisciplinary approach.

DESCRIPTION A 2-year-old boy presented with an atypical craniofacial cleft going through the right nostril with a soft-tissue extension of 2 × 1 cm. A computed tomographic scan showed bony involvement of the right nasal bone, right frontal bone, anterior cribriform plate anomalies, and no encephalocele.

From the Division of Plastic Surgery, Craniofacial Center, and Vascular Anomalies Center, Children’s Hospital (J.B.M.); the Department of Radiology (S.A.), Pediatric Service (R.A.B.E.), and the Department of Pathology, Division of Dermatopathology (M.C.M.), Massachusetts General Hospital; and the Departments of Surgery (J.B.M.), Radiology (S.A.), Pediatrics (R.A.B.E.), and Dermatology (M.C.M.),...

Nager syndrome is an extremely rare genetic condition, that this case is the first reported from Egypt. The affected infant manifested a severe phenotype with growth retardation and congenital heart defect. Limb anomalies are a cardinal sign and, in combination with the characteristic craniofacial features, are diagnostic.