BACKGROUND Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature. However, the reports are rare and have been mainly from intrathecal methotrexate in pediatric acute lymphoblastic leukemia patients who developed demyelinating polyradiculoneuropathy. CASE PRESENTATION A case report is presented of an unfortunate 53 year ...

Abstract BACKGROUND AND IMPORTANCE Third nerve palsies in the pediatric population are most commonly caused by trauma, tumors, or vascular abnormalities. Cystic oculomotor neuropathies, however, rare. We report case of a symptomatic cyst along and within nerve, which has not been described previously. CLINICAL PRESENTATION Here, we 3-yr-old girl presenting with progressive painless palsy. A mag...

CLINICAL PEARLS Lesions of the fourth (trochlear) cranial nerve cause vertical or oblique diplopia by impairing the ability of the superior oblique muscle to intort and depress the eye. This binocular diplopia worsens in downgaze and lateral gaze away from the affected eye. Because intorsion is necessary to maintain fusion in ocular counter-roll, this diplopia also worsens with head tilt toward...

During the past seven years 347 patients have been entered into a data bank at the Duke University Medical Center for evaluation of transient neurologic ischemia. One hundred fifty eight of these patients had carotid endarterectomies of whom 24 (15.1%) developed 26 (16.4%) peripheral cranial nerve palsies. Injury to the peripheral portion of the hypoglossal nerve was noted in 13 patients, to th...

Primary leptomeningeal lymphoma (PLML) is a rare entity, representing 7% of all cases of primary central nervous system lymphoma and approximately 0.1% of primary central nervous system tumours. Patients can present with symptoms of raised intracranial pressure, or cranial or spinal polyradiculopathies. Even with extensive investigations, diagnosis in up to a third of patients can only be confi...

We report on an unusual case of oro-rhinocerebral disease caused by mucormycosis and aspergillus co-infection in a 54-year-old insulin dependent diabetic patient. Although she was successfully treated with parenteral amphotericin B followed by oral posaconazole, she was left with irreversible blindness of the right eye and multiple cranial nerve palsies.

RATIONALE Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating th...

This report of 14 Thai patients describes the clinical features of a symptom-complex we have termed recurrent multiple cranial nerve palsies. While the disorder is common in South Eastern Asia, patients suffering similar symptoms have been seen in Europe and America. Characteristically, a long prodromal headache precedes the abrupt onset of multiple cranial nerve palsies affecting predominantly...