host, the macrophage. Macrophages containing BODIPY-labeled lipid droplets (LD, green) were infected with C. neoformans (Uvitex, blue). Not only do the host LD accumulate around the C. neoformans-containing phagosome (LAMP1, red), but the green signal is visible within C. neoformans, indicating direct and active scavenging of the lipids found within the macrophage LD by the fungi. (See related ...

glucoronoxylomannan (gxm) is the most important compound of polysaccharide capsule in cryptococcus neoformans that causes infection in its recognition as a foreign agent by immune system. because of its similarity with some naural compounds such as heparin and hyaloronic acid, this study was undertaken to determine the effect of polysaccharide compounds on blood coagulative process and renal pe...

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening pneumonia and meningoencephalitis in immune compromised individuals. Previous studies have shown that immunization of BALB/c mice with an IFN-gamma-producing C. neoformans strain, H99gamma, results in complete protection against a second pulmonary challenge with an otherwise lethal cryptococcal strain. The ...

INTRODUCTION Within the Cryptococcus neoformans species complex, two species and five serotypes are recognized: C. neoformans (var. grubii, serotype A; var. neoformans, serotype D and a hybrid, serotype AD) and C. gattii (serotypes B and C). Mating types a and alpha are designated by a single locus, with the mating type alpha being most prevalent in serotype A and D strains. OBJECTIVE To eval...

OBJECTIVE Cryptococcus neoformans is an important cause of central nervous system infection in adults with acquired immunodeficiency syndrome (AIDS) but an unusual cause of disease in children with AIDS. The basis for this age-related difference in incidence is not known but may be caused by differences in exposure or immune response. The objective of this study was to determine whether the low...

One of the differences observed between the two varieties of Cryptococcus neoformansis the greater difficulty to achieve an adequate therapeutical response in patients affected by C. neoformans var. gattii, an observation that has been validated in vitro only rarely. The aim of this work was to study the susceptibility patterns of 35 Colombian clinical isolates of C. neoformans, 20 of which bel...

The mechanism of human T-lymphocyte activation by the pathogenic yeast Cryptococcus neoformans has not been established. Previous investigations have suggested that C. neoformans contains a mitogen for T lymphocytes, while other investigators have attributed lymphocyte proliferation in vitro to a recall antigen. Because of the potential importance of the mechanism of T-cell activation for our u...