نتایج جستجو برای: cox model
تعداد نتایج: 2138147 فیلتر نتایج به سال:
COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...
Background: Parkinson's disease (PD) is a degenerative neurodopaminergic disease in nigrostriatum pathway of animals and human, the resultant loss of nerve terminals accompanied by dopamine-glutamate and other related neurotransmitters-imbalances in this pathway are responsible for most of the movement abnormalities. Increasing evidence suggests that an inflammatory reaction accompanies the pat...
We give a complete characterization of affine term structure models based on a general nonnegative Markov short rate process. This applies to the classical CIR model but includes as well short rate processes with jumps. We provide a link to the theory of branching processes and show how CBIprocesses naturally enter the field of term structure modelling. Using Markov semigroup theory we exploit ...
Introduction: Kidney transplantation is the best treatment for patients with advanced kidney diseases. The aim of this study was to determine the rate of transplanted kidney survival and compare the efficiency of Cox semi-parametric model with the parametric models in determination of survival effective factors. Method: This is a historic cohort study including the information of 381 ESRD pati...
Introduction: Neuropathy is a common complication of diabetes that can cause disability in diabetic patients. The aim of this study was to determine of affective factors in the Event Time of Neuropathy in type 2 diabetes using Cox proportional hazards model. Materials and Methods: This study included 371 patients with type II diabetes without neuropathy who were registered at Fereydunshahr diab...
Background and purpose: Prostate cancer is the second most common malignant cancer in men and radiotherapy is one of the treatments for this disease. The aim of this study was to determine the effect of demographic, clinical and pathology factors in survival rate of patients on radiotherapy and comparing different survival models to determine an efficient model. Materials and methods: In a his...
background: identification of disease risk factors can help in the prevention of diseases. in assessing the predictive value of continuous variables, a routine procedure is to categorize the factors. this yield to inability to detect non‑linear relationship, if exist. multivariate fractional polynomial (mfp) modeling is a flexible method to reveal non‑linear associations. we aim to demonstrate ...
Background & Aim: Fertility is the most important factors affecting population fluctuations. Reproductive behaviors of a community can be studied through different methods. One of the methods is the evaluation of the interval between marriage and the birth of the first child. The aim of this study was to investigate the factors influencing the interval between marriage and first birth using the...
در حال حاضر مهارکننده های انتخابی cox-2 توجه زیادی را در طراحی داروهای ضدالتهاب غیر استروئیدی (nsaids) به خود جلب کرده اند زیرا آن ها عاری از اثرات جانبی معمول nsaidsهای کلاسیک اند. تحقیق پیش رو بر طراحی مهارکننده های جدید انتخابی cox-2 متمرکز است. ابتدا مدل های سه بعدی آنزیم های cox با مدل سازی هم سانی ساخته شدند. به منظور ساختن مدل های هم-سانی coxs، توالی های آمینواسیدی coxs از وب سایت ncbi...
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