Objective(s): Nowadays, COX- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. In response to this, medicinal chemists have attempted to synthesize new classes of COX-2 Inhibitors.   Materials and Methods: In this study, three novel analogues of thiazolidin-4-ones derivatives ...

Background: In many studies, Cox regression was used to assess the important factors that affect the survival of cancer patients based on demographic and clinical variables. The aim of this study was to determine the factors affecting the survival of patients with Hodgkin's lymphoma using the random survival forest (RSF) method and compare it with the Cox model. Methods: In this retrospective ...

Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production. Recently , the discovery of different isoforms of this enzyme, Cyclooxygenase-1 (COX-1) andCyclooxygense-2 (COX-2), has led to the synthesis and introduction of novel drugs with select...

We study the differentiability of the CIR process with respect to its parameters. We give a stochastic representation for these derivatives in terms of the paths of V .

Research on modeling time series text corpora has typically focused on predicting what text will come next, but less well studied is predicting when the next text event will occur. In this paper we address the latter case, framed as modeling continuous inter-arrival times under a logGaussian Cox process, a form of inhomogeneous Poisson process which captures the varying rate at which the tweets...

• 類推研究における 2種類の関係性構造の抽出 (Reeves & Weisberg, 1994) − Automatic schema abstraction > 複数事例の記憶・再生の経験によって抽出 > 新規問題に対しては,特徴の適合度に基づき貯蔵された事例が活性化し,その表象によって抽 象的スキーマが形成される (Goldinger, 1998; Hintzman, 1986) − Comparison-based abstraction (Strategic schema abstraction) > 問題同士を顕在的に比較するときに行われる > 2つの問題に共通する関係構造に着目し,その関係性構造が元の問題とは別に保存される (Kotovsky & Gentner, 1996; Namy & Gentner, 2002; Ross, 1984, 1989; Ross & ...

We consider the intensity-based approach for the modeling of default times of one or more companies. In this approach the default times are defined as the jump times of a Cox process, which is a Poisson process conditional on the realization of its intensity. We assume that the intensity follows the Cox-Ingersoll-Ross model. This model allows one to calculate survival probabilities and prices o...