IntroductionCerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found cause local microstructural damage and disruption of white matter integrity. This study examines influence on cortical thickness in remote brain areas.MethodsSix small silent diffuse weighted imaging (DWI) lesions corresponding ...

Multiple sclerosis (MS) is thought to predominantly affect white matter (WM). Recently, however, loss of cortical gray matter has also been described. Little is known about the cause of cortical atrophy in MS, whether it occurs early in the disease course, and whether it affects all cortical regions equally or if there is a preferential pattern of focal cortical atrophy. An automated method was...

PURPOSE The analysis of the human cerebral cortex and the measurement of its thickness based on MRI data can provide insight into normal brain development and neurodegenerative disorders. Accurate and reproducible results of the cortical thickness measurement are desired for sensitive detection. This study compares ultra-high resolution data acquired at 7T with 3T data for determination of the ...

BACKGROUND Interregional cortical thickness correlations reflect underlying brain structural connectivity and functional connectivity. A few prior studies have shown that migraine is associated with atypical cortical brain structure and atypical functional connectivity amongst cortical regions that participate in sensory processing. However, the specific brain regions that most accurately diffe...