BACKGROUND Quantitative computed tomography (QCT) imaging is the basis for multiple assessments of bone quality in the proximal femur, including volumetric bone mineral density (vBMD), tissue volume, estimation of bone strength using finite element modeling (FEM), cortical bone thickness, and computational-anatomy-based morphometry assessments. METHODS Here, we present an automatic framework ...

Bone loss occurs during adulthood in both women and men and affects trabecular bone more than cortical bone. The mechanism responsible for trabecular bone loss during adulthood remains unexplained, but may be due at least in part to a reduced mechanoresponsiveness. We hypothesized that trabecular and cortical bone would respond anabolically to loading and that the bone response to mechanical lo...

the purpose of this study was to determine the influence of platform switching on stress distribution of two different implant systems using three-dimensional (3d) finite element models.six 3d finite element models were created to replicate two different implant systems with peri-implant bone tissue, in which six different implant-abutment configurations were represented: model xive-a: 3.8-mm-d...

To determine the effect of estrogen receptors (ER) α and β on bones' adaptive response to loading, we subjected the right tibiae of mice lacking ERα or ERβ activity to either axial loading or to disuse. Adaptive changes in architecture were assessed by comparing differences between the right (treated) and left (control) tibiae in these genotypes as assessed by microcomputed tomography. In femal...

High treatment failure rates and the need for prolonged antimicrobial therapy for osteomyelitis and implant-associated infections suggest that antimicrobial bone penetration may be incomplete. Assessment of the bone pharmacokinetics of antimicrobials is challenged by a lack of validated methods. In this study, 1000 mg of vancomycin was administered as a single dose over 100 min to eight female ...

Many bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-alpha-glycidyl dimethacrylate (Bis-GMA)-based resin, ...

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as potential prosthetic biomaterial used for cortical bone replacement. The results are compared with reference Ti c.p. biomaterials bone-replacement implants. estimated foams was also experimental fabricated by authors in previous studies. A 20–30% porosity could be candidate replacement bone, while levels ...

The use of allograft bone is becoming increasingly common. intrinsic mechanical and structural properties the graft are major importance for osseointegration. Current cleaning treatments using chemical or physical products increase biosafety but may disturb these characteristics. A new treatment cancellous cortical by simple washing (sonication centrifugation) supercritical carbon dioxide (scCO...

This study analyses the evaluation of tomographic indicators of tibia structure, assuming that the usual loading pattern shifts from uniaxial compression close to the heel to a combined compression, torsion and bending scheme towards the knee. To this end, pQCT scans were obtained at 5% intervals of the tibia length (S5-S95 sites from heel to knee) in healthy men and women (10/10) aged 20-40 ye...