OBJECTIVE Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy. Underlying mechanisms leading to these events are unknown; damage to the myocytes or vasospasms have been discussed. METHODS 102 consecutive and unselected patients were monitored with 12-lead ECG, echocardiography an...

Coronary heart disease affects over 15 million people in the USA, and approximately 9 million have angina pectoris [101]. However, this likely represents only the ‘tip of the iceberg’ of symptomatic chronic coronary disease syndromes (CCS), considering diffi culties with recognition of chest symptoms and access to medical care capable of making an appropriate diagnosis. In Americans aged 40–74 ...

Early Descriptions of Possible Angina Pectoris Notwithstanding the conditions prevailing before the eighteenth century, there were undoubtedly some few individuals who had the potential for development of ischaemic heart disease. This can occur in the absence of exogenous risk factors for coronary arteriosclerosis, for example, in rare homozygous subjects with familial abnormalities of choleste...

Refractory Angina Pectoris is a chronic pain condition relating to myocardial ischaemia in the presence of coronary artery disease despite optimal medical therapy. It affects cohort patients with subset perfusion deficiencies. While there no cure for these patients, an array and interventional treatment available 2021. In this article we discuss options explanation mechanisms action evidence th...

The relationship between serum neopterin levels and coronary heart disease (CHD) was investigated. Eighty-six CHD patients were divided into an acute myocardial infarction (AMI) group (N = 21), an unstable angina pectoris (UAP) group (N = 35), and a stable angina pectoris (SAP) group (N = 30), based on coronary angiography (CAG), 30 subjects without CHD served as the control group. Serum neopte...

AIMS Serum levels of neopterin, an immune modulator secreted by activated macrophages, are elevated in patients with acute coronary syndromes compared with stable angina patients and control subjects. In unstable angina, serum neopterin levels correlate with the presence of vulnerable coronary stenosis, multiple complex coronary lesions, and patient outcome. The present study assessed the progn...

Coronary heart disease (CHD) continues to be a worldwide leading cause of death for both men and women. When coronary atherosclerosis progresses, there is deposition of plaque external to the lumen of the artery, thus the plaque may extend eccentrically and outward without compromising the lumen initially. As atherosclerosis worsens the plaque mass may later on bulge into the lumen and may ther...

OBJECTIVE To assess prevalence and type of non-atherosclerotic coronary artery disease in young people (< or = 35 years) who died suddenly. DESIGN A necropsy study of 150 consecutive cases of sudden death (that is, within 6 h of the onset of symptoms). RESULTS Death was attributed to coronary artery disease in 48 cases: in 16 (33%) of them the disease was non-atherosclerotic. Twelve subject...

A 59 year old man was admitted to hospital with a non-transmural anterior myocardial infarction. Recurrent angina pectoris eight days after the initial infarction was investigated by cardiac catheterisation, which showed moderate anterior hypokinesis and proximal occlusion of the left anterior descending coronary artery. The distal part of this vessel was opacified via collaterals from the righ...