PURPOSE To determine whether the nerve fiber analyzer GDx with the new variable corneal compensation (VCC) device allows measurements of retinal nerve fiber layer parameters independent from birefringence changes of the cornea after photorefractive keratectomy (PRK). METHODS Retinal nerve fiber layers of 32 eyes in 32 myopic patients undergoing PRK were analyzed using the GDx-VCC. Photorefrac...

OBJECTIVE To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures. DESIGN This case series included a control subject and 9 eyes of 8 patients who had undergone phacoemulsification, Descemet membrane stripping endokeratoplas...

PURPOSE To develop and characterize a telomerase-immortalized human corneal epithelial cell line (hTCEpi) to serve as an in vitro model for studying the molecular mechanisms involved in regulating human corneal epithelial cell differentiation. METHODS Primary cultures of human corneal epithelial cells were infected with a retroviral vector encoding human telomerase reverse transcriptase (hTER...

AIMS To evaluate whether amniotic membrane transplantation can be an effective alternative treatment for neurotrophic corneal ulcers. METHODS Amniotic membrane transplantation was performed in 16 eyes of 15 patients with neurotrophic corneal ulcers and vision equal to or worse than 20/200. The neurotrophic state was developed following keratoplasty (four eyes), herpes zoster ophthalmicus (fou...

The Pax6 transcription factor functions early during embryogenesis to control key steps in brain, pancreas, olfactory and ocular system development. A requirement for Pax6 in proper formation of lens, iris and retina is well documented. By examining the corneas of heterozygous Small eye (SEY) mice, this report shows that Pax6 is also necessary for normal corneal morphogenesis. In particular, th...

BACKGROUND Avellino corneal dystrophy (ACD) is an autosomal dominant disorder, characterized by the presence of deposits in the anterior stroma, and results from a specific mutation (R124H) in the transforming growth factor beta-induced gene (TGFBI). This report presents corneal dystrophy of the Bowman layer as a rare phenotypic appearance of ACD and a high intra-familial variability of phenoty...

The retina shows atrophic changes in the ganglion cell and nerve fibre layers, and there is cystic degeneration at the ora serrata and periphery of the retina. 'The lamina cribrosa is displaoed backwards. Diagnosis.-Sclerosing keratitis profunda. Secondary glaucoma. Commentary.-Pathologically the corneal lesion has predominant chronic inflammatory characters, such degenerative changes as are pr...