Dementia describes the loss of brain function that occurs with certain diseases, and which has the potential to affect memory, thinking, language, judgment, and behavior. Most types of dementia involve irreversible neurodegeneration, and Alzheimer's disease (AD) is the most common form. Beyond AD however, there are many other diseases that can lead to dementia including dementia with Lewy bodie...

Thyroid scintigraphy is a method that formed more than 60 years ago and retains its importance for the diagnosis assessment of risk nodular malignancy. The review examines use scintigraphic in functional metabolic goiter. Prerequisites thyroid nodes screening with short-lived 99mTc-pertechnetate are outlined. Information provided on principles preparation pharmacokinetics, as well variants acti...

A Radiopharmaceutical is a radioactive compound used for the diagnosis and treatment of human diseases. Radiopharmaceuticals are among the most highly regulated materials administered to patients because they are controlled both as drugs and as radioactive substances. The use of radiopharmaceuticals for any purpose is governed by regulatory agencies in different countries all over the wor...

This article describes the 30-y history of nuclear medicine in Brazil, including reactors, production of radiopharmaceuticals, and trends.

The construction of the 68Ge/68Ga generator has increased application of radiopharmaceuticals labeled with this isotope in medicine. 68Ga-PET is widely employed in the management of neuroendocrine tumors but favorable chemistry with tri- and tetraaza-ring molecules has opened wide range of 68Ga application in other fields of PET imaging. This review covers the radiopharmaceuticals labeled with ...

Nuclear imaging techniques play a role in the assessment and management of patients with sarcoidosis. A variety of radiopharmaceuticals have been introduced for this purpose since the late 1970s. The present chapter focuses on these radiopharmaceuticals, scintigraphic imaging techniques, and their role and clinical value in sarcoidosis. Correlation with other imaging modalities, biochemical par...

The task of single photon emission CT (SPECT) is to visualize the physiological function of various organs with the help of radiopharmaceuticals. But the projection data used for image reconstruction are distorted by several factors, making the reconstruction of a quantitative SPECT image very difficult in most cases. These factors include the attenuation and scattering of gamma rays, collimato...

In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes ...