A continuous compact membrane bioreactor consisted of ceramic-supported graphene oxide (CSGoM) was implemented for the first time anaerobic biodecolorization monoazo Acid Orange 7 (AO7), diazo Reactive Black 5 (RB5), and triazo Direct Blue 71 (DB71) solutions, showing excellent decolorization potential. The prepared by vacuum filtration various solutions using a UF ceramic flat element. efficie...

Textile effluents are highly polluting and have variable and complex compositions. They can be extremely complex, with high salt concentrations and alkaline pHs. A fixed-bed bioreactor was used in the present study to simulate a textile effluent treatment, where the white-rot fungus, Trametes versicolor, efficiently decolourised the azo dye Reactive Black 5 over 28 days. This occurred under hig...

The steady-state production of a product produced through the growth of microorganisms in a continuous flow bioreactor is presented. A generalised reactor model is used in which both the classic well-stirred bioreactor and the idealised membrane bioreactor are considered as special cases. The reaction is assumed to be governed by Monod growth kinetics subject to non-competitive product inhibiti...

Two continuous-flow bench-scale bioreactor systems populated by mixed communities of acidophilic sulfate-reducing bacteria were constructed and tested for their abilities to promote the selective precipitation of transition metals (as sulfides) present in synthetic mine waters, using glycerol as electron donor. The objective with the first system (selective precipitation of copper from acidic m...

In many tissue engineering approaches, the basic difference between in vitro and in vivo conditions for cells within three-dimensional (3D) constructs is the nutrition flow dynamics. To achieve comparable results in vitro, bioreactors are advised for improved cell survival, as they are able to provide a controlled flow through the scaffold. We hypothesize that a bioreactor would enhance long-te...

Adoptive cell therapy (ACT) for metastatic melanoma involves the ex vivo expansion and reinfusion of tumor infiltrating lymphocytes (TIL) obtained from resected specimens. With an overall objective response rate of 56%, this T-cell immunotherapy provides an appealing alternative to other therapies, including conventional therapies with lower response rates. However, there are significant regula...

Bioengineered functional cardiac tissue is expected to contribute to the repair of injured heart tissue. We previously developed cardiac cell sheets using mouse embryonic stem (mES) cell-derived cardiomyocytes, a system to generate an appropriate number of cardiomyocytes derived from ES cells and the underlying mechanisms remain elusive. In the present study, we established a cultivation system...

A continuous two-phase partitioning bioreactor (C-TPPB), operated with coiled tubing made of the DuPont polymer Hytrel 8206, was tested for the bioremediation of 4-chlorophenol, as a model toxic compound. The tubing was immersed in the aqueous phase, with the contaminated water flowing tube-side, and an adapted microbial culture suspended in the bioreactor itself, with the metabolic demand of t...

A controller based on neuro-dynamic programming coupled with a fuzzy ARTMAP neural network for a fed-batch bioreactor was developed to roduce cloned invertase in Saccharomyces cerevisiae yeast in a fed-batch bioreactor. The objective was to find the optimal glucose feed rate profile eeded to achieve the highest fermentation profit in this reactive system where the enzyme expression is repressed...