PURPOSE To assess subjective comfort during the first three months of continuous wear of hyper-transmissible soft and rigid contact lenses. METHODS One hundred subjects (50 experienced wearers and 50 neophytes) were fitted with either the Focus Night & Day lens (CIBA Vision, Duluth, GA) or the Z alpha lens (Menicon, Nagoya, Japan). Comfort was monitored at regular intervals using a vertical a...

PURPOSE Innovations in contact lens materials and designs allow patients to wear contact lenses during sleep to flatten the cornea and temporarily to reduce myopic refractive error and improve unaided visual acuity. We conducted the Children's Overnight Orthokeratology Investigation (COOKI) pilot study, a case series, to describe the refractive error and visual changes, as well as the slitlamp ...

PURPOSE To investigate compliance with daily disposable contact lens (DDCL) wear and investigate re-use of lenses according to country and DDCL material worn. METHODS Optometrists invited eligible DDCL patients from their practices to participate in a survey on DDCL wear in Australia, Norway, the United Kingdom (UK) and the United States (US). Eligible participants completed an online or pape...

PURPOSE This study investigated short-term corneal changes induced by reverse-geometry lenses worn for orthokeratology. METHODS Nine young adult subjects wore reverse-geometry rigid gas-permeable lenses (BE; UltraVision Contact Lenses, Brisbane, Australia) in one eye only for 10, 30, and 60 min in the open eye and 8 h in the closed eye. The fellow eye acted as a non-lens-wearing control. Corn...

Purpose We have previously shown that invasive strains of Pseudomonas aeruginosa exploit the robust neutrophil response to form biofilms on contact lens surfaces and invade the corneal epithelium. The present study investigated the ability of multiple bacterial genera, all commonly recovered during contact lens-related infectious events, to adhere to and form biofilms on contact lens surfaces i...

PURPOSE Covalent immobilization of antimicrobial peptide melimine onto contact lenses can produce broad-spectrum antimicrobial lenses. The purpose of this study was to investigate the performance of melimine-coated contact lenses in an animal model and human clinical trial. METHODS Melimine was covalently attached onto the surface of contact lenses via EDC (1-ethyl-3-[3-dimethylaminopropyl] c...

AIM To determine the incidence of non-severe keratitis (NSK) and severe keratitis (SK) among wearers of current generation contact lenses. METHODS A 12 month, prospective, hospital based epidemiological study was conducted by examining all contact lens wearers presenting with a corneal infiltrate/ulcer to a hospital centre in Manchester. A clinical severity matrix was used to differentiate be...

Pubmed and Medline were searched for articles referring to Pseudomonas keratitis between the years 2007 and 2012 to obtain an overview of the current state of this disease. Keyword searches used the terms "Pseudomonas" + "Keratitis" limit to "2007-2012", and ["Ulcerative" or "Microbial"] + "Keratitis" + "Contact lenses" limit to "2007-2012". These articles were then reviewed for information on ...

PURPOSE To report a case of severe bilateral deep stromal neovascularization and opacification associated with unmonitored contact lens wear. DESIGN Observational case report. METHODS A 46-year-old woman who had been using hydrogel contact lenses bought on the Internet without a prescription for 5 years was found to have dense, bilateral corneal opacities with deep stromal neovascularizatio...

OBJECTIVES The aim of this study was to measure tear film surface quality (TFSQ) using dynamic high-speed videokeratoscopy during short-term (8 hrs) use of rigid and soft contact lenses. METHODS A group of 14 subjects wore 3 different types of contact lenses on 3 different nonconsecutive days (order randomized) in 1 eye only. The subjects were screened to exclude those with dry eye. The lense...