This experiment explored the effects of controlled manipulations of three parameters of tactile gratings, groove width (1.07-2.53 mm), contact force (30-90 g), and scanning speed (40-120 mm/s), on the responses of cells in second somatosensory cortex (SII) of awake monkeys that were performing a groove-width classification task with passively presented stimuli. A previous experiment involving a...

Slowed gait in patients with Parkinson's disease (PD) can be improved when patients synchronize footsteps to isochronous metronome cues, but limited retention of such improvements suggest that permanent cueing regimes are needed for long-term improvements. If so, music might make permanent cueing regimes more pleasant, improving adherence; however, music cueing requires patients to synchronize ...

This experiment explored the relationship between neural firing patterns in second somatosensory cortex (SII) and decisions about roughness of tactile gratings. Neural and behavioral data were acquired while monkeys made dichotomous roughness classifications of pairs of gratings that differed in groove width (1.07 vs. 1.90 and 1.42 vs. 2.53 mm). A computer-controlled device delivered the gratin...

The double-stranded DNA of the genome contains both sequence information directly relating to the protein and RNA coding as well as functional and structural information relating to protein recognition. Only recently is the importance of DNA shape in this recognition process being fully appreciated, and it also appears that minor groove electronegative potential may contribute significantly in ...

‎in this paper, using the idea of convexificators, we study boundedness and nonemptiness of lagrange multipliers satisfying the first order necessary conditions. we consider a class of nons- mooth fractional programming problems with equality, inequality constraints and an arbitrary set constraint. within this context, define generalized mangasarian-fromovitz constraint qualification and show t...

Pax proteins are a family of transcription factors conserved during evolution and able to bind specific DNA sequences through a domain called a "paired domain'. The DNA-binding specificity of the Pax-8 paired domain was investigated. Site-selection experiments indicate that Pax-8 binds to a consensus sequence similar to those bound by Pax-2 and Pax-5. When consensus sequences of various paired ...

Abstract We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, demonstrate their significant roles shaping optical response of plasmonic gratings. Within framework width-graded metal–insulator-metal nano-gratings, electromagnetic field confinement wave guiding result multiwavelength light localization provided conditions adiabat...

For this paper, studies of the microstructure as well mechanical and biological properties bioinert titanium, zirconium, niobium alloys in their nanostructured (NS) ultrafine-grained (UFG) states have been completed. The NS UFG were formed by a combined two-step method severe plastic deformation (SPD), first with multidirectional forging (MDF) or pressing into symmetrical channel (PSC) at given...