نتایج جستجو برای: consanguineous population
تعداد نتایج: 696035 فیلتر نتایج به سال:
Objectives: The prevalence of consanguineous marriage is about 30 % in Iran and this can increase the probability of incidence of genetic impairments such as hearing impairments. Hearing impairment in comparison with other hereditary disorders is the most incident. The purpose of this survey is to identify the prevalence of consanguinity among the parents of sensoryneural hearing impaired stude...
Purpose The Pakistan Punjab population has been a rich source for identifying genes causing or contributing to autosomal recessive retinal degenerations (arRD). This study was carried out to delineate the genetic architecture of arRD in the Pakistani population. Methods The genetic origin of arRD in a total of 144 families selected only for having consanguineous marriages and multiple members...
Abstract Background Consanguineous marriage is widely practised across the world. Its effect on acute lymphoblastic leukaemia (ALL) controversial as both parents share some of genes which might increase incidence sharing recessive genes. However, other theories suggest that consanguinity have a protective factor it does for types cancers. This study aims to childhood ALL and consanguinity. Meth...
Many different types of genetic disorders are noted to be prevalent among consanguineous progeny. Although the most common type of consanguineous union in all major societies is between first cousins, the importance of customary influences is apparent from variations in the specific types of first-cousin marriages contracted. Epidemiological data for the prevalence of whistling-face syndrome (W...
Almost half of all marriages in Pakistan are consanguineous. Despite its high prevalence, little is known about the change over time consanguineous unions Pakistan. Examining patterns cousin particularly important given substantial improvement women’s education which often associated with decline across world. Our analysis, based on four waves nationally representative Demographic and Health Su...
In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles. Although this phenomenon is well studied in general, here some hitherto unstudied cases are presented. An analytical f...
Arranged marriage is where parents choose marital partners for their children. It is a norm in many parts of Asia and Middle East. A marriage is said to be consanguineous where the marriages are solemnized among persons with close biological relations. There is considerable overlap in arranged and consanguineous marriages with many cultures adopting both practices. Recent studies showed that th...
NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans are limited by the lack of large cohorts and the incomplete assessment of family members. We hypothesized that studying the role of NKX2-5 in inbred populations with homogeneous genetic backgrounds and high co...
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