Modulation of glucocorticoid resistance in pediatric T-cell Acute Lymphoblastic 1 Leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235 2 3 Connor P. Hall , C. Patrick Reynolds, Min H. Kang 4 5 Cancer Center, Pharmacology and Neuroscience, Cell Biology & Biochemistry, Pediatrics, 6 Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 7 Lubbock...

Modulation of glucocorticoid resistance in pediatric T-cell Acute Lymphoblastic 1 Leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235 2 3 Connor P. Hall , C. Patrick Reynolds, Min H. Kang 4 5 Cancer Center, Pharmacology and Neuroscience, Cell Biology & Biochemistry, Pediatrics, 6 Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 7 Lubbock...

The clinical significance and ophthalmoscopic features of angioid streaks have received considerable attention in the ophthalmic literature (Paton, I962; Paton, 1972; Connor, Juergens, Perry, Hollenhorst, and Edwards, I96I). Angioid streaks usually have a characteristic ophthalmoscopic appearance and diagnosis is easy. In some instances, however, they may be subtle or may simulate other more co...

Parkinson’s disease (PD) is a disabling motor disorder that affects all kinds of movements. In the early stages of PD, patients have difficulty with walking, speaking, or getting in and out of chairs (Gibbert 1986). As the disease progresses, all movements are affected resulting at the end of the disease a complete inability to move. Patients require intense concentration to overcome the appare...

* Correspondence: C. H. Frère, School of Biological E University of New South Wales, Sydney, NSW 2052, A E-mail address: [email protected] (C.H. Frère). 1 M. Krützen is at the Anthropological Institute Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Sw 2 J. Mann, Y. J. Tsai and E. M. Patterson are at the Psychology, Georgetown University, Washington DC 2 3 J. J. Watson-Capps is at the Biology ...

Introduction: Hormonal replacement therapy (HRT) has been used extensively to treat the symptoms caused by decreased estrogen production following menopause, which can include vasomotor symptoms, urogenital atrophy, and mood or sleep disturbances (Ryan & Rosner, 2001). Estrogen therapy is frequently used in HRT and its pro-proliferative effects on the endometrium are counterbalanced by the use ...

A classification of spiking neurons according to the transition from quiescence to periodic firing of action potentials is commonly used. Nonbursting neurons are classified into two types, type I and type II excitability. We use simple phenomenological spiking neuron models to derive a criterion for the determination of the neural excitability based on the afterpotential following a spike. The ...

A biplane is a 2-(k(k − 1)/2 + 1, k, 2) symmetric design. Only sixteen nontrivial biplanes are known: there are exactly nine biplanes with k < 11, at least five biplanes with k = 11, and at least two biplanes with k = 13. It is here shown by exhaustive computer search that the list of five known biplanes with k = 11 is complete. This result further implies that there exists no 3-(57, 12, 2) des...

Intensive selection of sires is possible by using artificial insemination; coupled with accurate measurement of a potential sire’s genetic value, this has markedly improved genetics for easily measured traits like milk production and type traits. Increased milk production has in turn increased gross feed efficiency through dilution of maintenance. Additional genetic gains in feed efficiency wou...

Latha P. Palaniappan, MD, MS, FAHA, Chair; Maria Rosario G. Araneta, PhD; Themistocles L. Assimes, MD, PhD; Elizabeth L. Barrett-Connor, MD, FAHA; Mercedes R. Carnethon, PhD, FAHA; Michael H. Criqui, MD, MPH, FAHA; Gordon L. Fung, MD, PhD, MPH, FAHA; K.M. Venkat Narayan, MD, MSc, FAHA; Hamang Patel, MD; Ruth E. Taylor-Piliae, PhD, RN; Peter W.F. Wilson, MD, FAHA; Nathan D. Wong, PhD, FAHA; on b...