Maryam Najafi, Sousan Kolahi, Mohaddeseh Mokhtarkhani. Medical Student, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Professor, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Student, Evidence Based Medicine Center of Excellence, Connective Tissue Diseases Research Center, Tabriz Univer...

Mohaddeseh Mokhtarkhani, Sousan Kolahi, Maryam Najafi. Medical Student, Evidence Based Medicine Center of Excellence, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Professor, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Student, Connective Tissue Diseases Research Center, Tabriz Univer...

Interstitial lung disease is a common complication of many of the connective tissue diseases. Because the prognosis, degree of reversibility, and optimal therapy differs for each disease presentation, a thorough knowledge of the pulmonary presentations of each connective tissue disease is important. Additionally, the challenge of finding the patient who has occult connective tissue disease in a...

BACKGROUND Liver disease is rare in the course of mixed connective tissue disease. Most commonly liver steatosis or elevated liver function tests are reported and only a few cases of mixed connective tissue disease associated with autoimmune hepatitis were described. CASE PRESENTATION We report a case of an 11-year old boy with hepatitis on admission to the hospital and symptoms and signs of ...

The conjugated lipids of connective tissue of the rat and rabbit obtained by the sponge-biopsy technic and the aortic intima of the rabbit were divided into two portions by differential saline solubility and the saline-soluble portion was further fiiictionated into the alpha and beta fractions of Colin. No apparent relationship was observed between the protein, amino acids or lipids of the seru...

The normal structure and function of the human lung is dependent on the maintenance of the connective tissue matrix. These structural macromolecules provide the template for normal parenchymal cell architecture on which efficient gas exchange depends. In addition, the organization and amount of this extracellular matrix accounts for much of the mechanical behavior of the lung parenchyma during ...

Connective tissues support organs and play crucial roles in development, homeostasis and fibrosis, yet our understanding of their formation is still limited. To gain insight into the molecular mechanisms of connective tissue specification, we selected five zinc-finger transcription factors - OSR1, OSR2, EGR1, KLF2 and KLF4 - based on their expression patterns and/or known involvement in connect...

Pectus excavatum, the most frequent congenital chest wall deformity, may be rarely observed as a sole deformity or as a sign of an underlying connective tissue disorder. To date, only few studies have described correlations between this deformity and heritable connective tissue disorders such as Marfan, Ehlers-Danlos, Poland, MASS (Mitral valve prolapse, not progressive Aortic enlargement, Skel...

Acupuncture meridians traditionally are believed to constitute channels connecting the surface of the body to internal organs. We hypothesize that the network of acupuncture points and meridians can be viewed as a representation of the network formed by interstitial connective tissue. This hypothesis is supported by ultrasound images showing connective tissue cleavage planes at acupuncture poin...

A great deal af the current interest in the connective tissues has been focused on the extracellular components of these tissues, particularly collagen and the mucopolysaccharides. Alterations in the amounts and in the physical and chemical properties of these extracellular components have been implicated as contributing factors in many abnormal and diseased states such as rheumatoid arthritis,...