Conjunctival xerosis (X1A) as an independent indicator of VAD: VAD is only one of the several causes of conjunctival xerosis; thus the reliability of this sign (X1A) for independent assessment of VAD in field conditions is questionable [3,4]. Conjunctival xerosis is clinically expressed as marked dryness or unwettability; the affected area appears roughened, with fine droplets or bubbles on the...

Angioimmunoblastic T-cell lymphoma (AITL) represents an uncommon variant of T-cell lymphomas and most often presents insidiously with systemic symptoms. This report constitutes the first documented case of conjunctival AITL, masquerading as nodular episcleritis, and describes both the clinical and pathological findings. Furthermore, conjunctival T-cell lymphoma in general remains a rare occurre...

PURPOSE To report the identification of human papillomavirus types in four cases of conjunctival papillomas and to review the literature regarding human conjunctival papillomavirus (HPV). METHODS Specimens from conjunctival papillomas of four patients were analyzed for the presence of HPV by polymerase chain reaction and subsequent filter hybridization. HPV types 6, 11, 16, 18, 31, and 33 wer...

clinically misdiagnosed as choroidal melanoma. Currently, most subretinal tumors assumed to be choroidal melanomas are treated with radiotherapy without histological confirmation. The diagnosis of an RPE carcinoma may therefore be missed. Finger et al described a darkly pigmented subretinal tumor accompanied by inflammation that was suspected of being an adenocarcinoma of the RPE. In several pu...

BACKGROUND Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is a rare, low-grade, non-Hodgkin's B-cell lymphoma. Herein, we report our successful management of the large conjunctival defect caused by resection of conjunctival MALT lymphoma by covering it with transplanted amniotic membrane. CASE A 28-year-old Japanese man, who had been diagnosed histologically as having conjunct...

BACKGROUND Differential expression of chemokine genes were investigated in various types of ocular surface cells. METHODS Primary cultures of human corneal epithelial cells (n = 3), corneal fibroblasts (n = 2), conjunctival epithelial cells (n = 2) and conjunctival fibroblasts (n = 2) were established and incubated with or without interleukin (IL)-4 (30ng/ml) and tumor necrosis factor (TNF)-a...

PURPOSE To elucidate the status of the conjunctival inflammation in atopic keratoconjunctivitis (AKC) using laser scanning confocal microscopy and compare the relevant findings with conjunctival brush cytology in a prospective controlled study. METHODS Twenty eyes from 20 AKC patients as well as 16 eyes from 16 age and sex matched normal subjects were studied. The subjects underwent tear film...

INTRODUCTION The purpose of this study was to examine and compare the conjunctival irritation (congestion, swelling, and discharge) of topical bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03% in rabbits. METHODS Six healthy New Zealand White rabbits were treated with either bimatoprost 0.01% or bimatoprost 0.03% (3 animals/group). One dose (2 drops/dose) of stud...

PURPOSE To determine whether human conjunctival epithelium expresses any of the human mucin genes designated MUC2 through MUC7. METHOD Northern blot analysis was performed using total RNA isolated from surgically removed conjunctival tissues. Complementary DNA or oligonucleotides to the tandem repeat region of each mucin gene were labeled and hybridized to conjunctival RNA. In situ hybridizat...

The authors examined immunofluorescently the specific cytokeratin staining patterns of corneal, limbal, and conjunctival epithelium with PKK-1, 8.12, 4.62, and 8.60 monoclonal anticytokeratin antibodies. Observations were made on unfixed frozen postmortem human tissue. The PKK-1 antibody stain was observed in all layers of corneal epithelium but only in suprabasal layers of limbal and conjuncti...