heat exchangers are the critical components of refrigeration and liquefaction processes. selection of appropriate operational conditions for cryogenic recuperative heat exchanger and expansion valve operating in joule-thomson cooling system results in improving the performance and efficiency. in the current study, a straightforward procedure is introduced to design an efficient joule-thomson co...

Vimentin coiled-coil alpha-helical dimers are elementary protein building blocks of intermediate filaments, an important component of the cell’s cytoskeleton that has been shown to control the large-deformation behavior of eukaryotic cells. Here we use a combination of atomistic simulation and continuum theory to model tensile and bending deformation of single alpha-helices as well as coiled-co...

Coiled coils is an important 3-D protein structure with two or more stranded alpha-helical motif wounded around to form a “knobs-into-holes” structure. In this paper we propose an SVM classification approach to predict the antiparallel coiled coils structure based on the primary amino acid sequence. The training dataset for the machine learning are collected from SOCKET database which is a SOCK...

The vasodilator-stimulated phosphoprotein (VASP) is a key regulator of actin dynamics. We have determined the 1.3-A resolution crystal structure of the 45-residue-long tetramerization domain (TD) from human VASP. This domain forms a right-handed alpha-helical coiled-coil structure with a similar degree of supercoiling as found in the widespread left-handed coiled coils with heptad repeats. The ...

the key to successful long-term peritoneal dialysis (pd) is permanent and safe access to peritoneal cavity. the two most commonly used tenckoff catheters for pd are the straight and coiled catheters. the present study was undertaken to assess the catheter survival, catheter associated infections, and all cause mortality and to compare the straight with coiled catheters in pd. during april 1997-...