BACKGROUND Development of congenital rubella syndrome associated with rubella virus infection during pregnancy is clinically important, but the pathogenicity of the virus remains unclear. METHODS Pathological examination was conducted on 3 aborted fetuses with congenital rubella infection. FINDINGS At autopsy, all 3 aborted fetuses showed congenital cataract confirmed by gross observation. ...

Rubella infection in pregnant women during the first trimester of pregnancy can lead to fetal anomalies, commonly known as congenital rubella syndrome (CRS). The objective of our study was to analyze the serological test results among infants suspected of having CRS aged < or = 12 months compared with their clinical status. Between January 2002 and December 2011, 3,279 serum samples from infant...

Epidural hematoma in newborns is rare, it occurs more frequently in infants born from nulliparous mothers with delivery difficulties. Intracranial hemorrhage in infants is usually secondary to vascular malformations, anticoagulation, inherited or acquired coagulopathy. Hematological disorders are infrequently associated with congenital rubella. The main defects of the disease associate deafness...

Persistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary valve and vascular tree but a PAP = 40 mmHg. The infant promptly responded to inhaled nitric oxide...

Introduction Rubella immunisation was introduced in the UK in 1970 with the aim of preventing congenital rubella syndrome (CRS) by the selective vaccination of schoolgirls and susceptible adult women. An augmented immunisation policy, aimed at eliminating circulating rubella by the mass vaccination of children of both sexes, was adopted in October 1988 with the introduction of the combined meas...

conclusions more than 95% of 15 to 25 year-old women (main reproductive age in iran) are within acceptable immunity range. level of immunity to rubella in women of reproductive age in this region appears satisfactory. patients and methods this descriptive cross-sectional study was conducted on 760 women younger than 25 years attending medical centers in ahvaz. a sample of 3 ml of venous blood w...

Background. Congenital and developmental cataracts are leading causes of childhood blindness and severe visual impairment. They may be associated with systemic diseases including congenital heart diseases which are among the major causes of morbidity and mortality in childhood. The pattern of systemic comorbidities seen in children diagnosed with cataract in Calabar, Nigeria, was studied. Metho...

In-utero transmission of rubella virus during pregnancy leads to congenital Rubella syndrome (CRS), which is characterized by cataracts, deafness and sensorineural hearing loss. While the nuclear cataract is the most frequently occurring abnormality, basal ganglia calcification is a rarer manifestation. The Risk of fetal transmission of rubella virus is highest during the first 12 weeks of gest...