nevus lipomatosus cutaneous superficialis is a rare idiopathic hamartomatous anomaly of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. the classic, or solitary type, presents with asymptomatic soft, skin-colored to yellow papules or nodules. we report the case of a 12-year-old boy with congenital, classical nevus lipomatosus cuta...

Piebaldism is an autosomal dominant uncommon (<1 in 20,000) congenital pigmentary disorder. Depigmented patches are present since birth. They usually remain unchanged throughout life. Vitiligo is its closest differential diagnosis. We report a unique family in which these two dissimilar depigmentations, i.e. piebaldism and vitiligo (with nevus depigmentosus), were noted in two brothers. T...

Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater freque...

neous biopsies, yielding 69 collision tumors. Cascajo and colleagues found 54 collision tumors of malignant cutaneous neoplasms associated with seborrheic keratoses in 85,000 biopsies. The most common combinations found by Boyd and Rapini included basal cell carcinoma and nevus (14), basal cell carcinoma and seborrheic keratosis (8), nevus and seborrheic keratosis (14), actinic keratosis and ne...

Congenital melanocytic nevi (CMN) are defined as melanocytic nevi that present at birth or within the first few months of life. Small or medium-sized nevi occur in approximately 1% to 6% of all newborns, whereas giant nevi occur in approximately 1 in 20,000 [1-3]. There are two main considerations in the treatment of CMN. The first is predicting the risk of its transformation to melanoma, and t...

Nevus lipomatosus cutaneous superficialis is a rare idiopathic hamartomatous anomaly of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. The classic, or solitary type, presents with asymptomatic soft, skin-colored to yellow papules or nodules. We report the case of a 12-year-old boy with congenital, classical nevus lipomatosus cuta...

Neurocutaneous melanosis is a rare neurocutaneous syndrome defi ned by the presence of multiple and /or giant congenital cutaneous nevi and melanocytic deposits in the central nervous system with the infi ltration of leptomeninges. The major medical concern with giant congenital cutaneous nevi is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanosis. ...

Eccrine porocarcinoma is a rare malignant skin tumor that often presents as the transformation of an underlying poroma. Nevus sebaceous benign hamartoma, from which various secondary neoplasm may arise. Since these tumors arise long-standing precursor lesions, multi-sampling, genomic analysis provide us with insight into life history tumors. Whole exome sequencing showed high intra-tumor hetero...