Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, have low leptin levels. In the context of open-label, uncontrolled studies leptin administration, in physiological replacement doses, has been shown to have metabolically sa...

Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted olig...

The basic properties of generalized parton distributions (GPDs) and some recent applications of GPDs are discussed. Talk given at the Workshop “Continuous Advances in QCD 2004”, Minneapolis, May 13-16, 2004 Also at Laboratory of Theoretical Physics,JINR, Dubna, Russia

In this paper, we introduce fractional-order into a model of HIV-1 infection of CD4+ T cells. We study the effect of the changing the average number of viral particles N with different sets of initial conditions on the dynamics of the presented model. Generalized Euler method (GEM) will be used to find a numerical solution of the HIV-1 infection fractional order model.

The generalized estimating equations (GEE) approach is commonly used to model incomplete longitudinal binary data. When drop-outs are missing at random through dependence on observed responses (MAR), GEE may give biased parameter estimates in the model for the marginal means. A weighted estimating equations approach gives consistent estimation under MAR when the drop-out mechanism is correctly ...

A coupled-mode analysis of 2-D generalized transverse Bragg waveguides (GTBW) with tilted distributed Bragg reflectors is presented. As a result of the absence of inversion symmetry about a plane perpendicular to the guiding stripe, the modes supported by these guides are not separable into the familiar form of transverse standing wave and longitudinal traveling-wave components. This fundamenta...