An analysis of the occurrence of nonglycyl residues in conformations disallowed in the Ramachandran plot is presented. Ser, Asn, Thr, and Cys have the highest propensities to exhibit such conformations, and the branched aliphatic residues the lowest. Residues cluster in five regions and there are some trends in the types of residues and their side-chain conformations (chi(1)) occupying these. M...

Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the conformational rearrangements underlying the gating of these channels are still unknown. Here, we image ligand-induced conformational changes in s...

Activation of G-protein coupled receptors by agonists is thought to involve the stabilisation of a ternary complex of agonist/receptor/G-protein, leading to effector activation, but this mechanism may be an oversimplification, as follows: (a) Agonist binding to the free receptor (uncoupled from G-proteins) is not a neutral event, but includes a component of the activation process and may be des...

We examine the conformations of a model for short closed DNA. The molecule is represented as a cylindrically symmetric elastic string with a constraint corresponding to a specification of the linking number. We obtain analytic expressions for configuration, elastic energy, twist and linking number for a family of solutions spanning from a circle to a ’figure eight’. We suggest ways to use our c...

ABSTRACT: Breeding strategies aim to reduce lameness in dairies by using predictor traits increase the selection of dairy cows. This study enhanced present knowledge about association between claw conformations (CC), hindlimb conformation (HiLC), gait, and body condition score (BCS) A total 166 lactating Holstein cows were enrolled scored for BCS, CC, HiLC, gait. The abnormal HiLC group was sta...