Stereotactic ablative radiotherapy (SABR) is the main treatment for inoperable early-stage non-small cell lung cancer (NSCLC). Despite the widespread use of SABR, the biological determinants of response to SABR remain poorly investigated. We developed an orthotopic NSCLC animal model to study the response to clinically-relevant doses of SABR. Image-guided intra-thoracic injection of NSCLC cells...

We calculate and discuss the one-loop corrections to the photon sector of QED interacting to a background gravitational field. At high energies the fermion field can be taken as massless and the quantum terms can be obtained by integrating conformal anomaly. We present a covariant local expression for the corresponding effective action, similar to the one obtained earlier for the gravitational ...

Introduction: Nowadays,  considerable developments  in  the field  of  radiotherapy have  been  achieved.  They  include  the  advances  made  in  the  equipments  and  treatment  planning  techniques  which  require  highly complex calculations. Such achievements have made it possible to treat cancer patients not only  with  higher  radiation  dose  but  also  with  higher  precision  and  con...

Although much literature has been devoted to portal dosimetry with the Varian amorphous silicon (aSi) portal imager, the majority of the described methods are not routinely adopted because implementation procedures are cumbersome and not within easy reach of most radiotherapy centers. To make improved portal dosimetry solutions more generally available, we have investigated the possibility of c...

Purpose More than 6,500 megavoltage teletherapy units are needed worldwide, many in low-resource settings. Cobalt-60 units or linear accelerators (linacs) can fill this need. We have evaluated machine performance on the basis of patient throughput to provide insight into machine viability under various conditions in such a way that conclusions can be generalized to a vast array of clinical scen...

Abstract We show the ACIS trap maps developed for the CTI correction algorithm can be applied to the GRADED mode data. The technique uses the fltgrade information available in the GRADED mode telemetry, and average 3 × 3 PHAS images for each fltgrade pre-calibrated using the FAINT mode data. The results (recovery of photon energies and energy resolution) are nearly identical to those from the C...

The many applications of Monte Carlo modelling in PET arouse to increase the accuracy and computational speed of Monte Carlo codes. The accuracy of Monte Carlo simulations strongly depends on cross-section libraries used for photon transport calculations. Furthermore, large amounts of CPU time are required to obtain meaningful simulated data. We present a comparison of different photon cross-se...

results no correlation between as and history of rt, rt-to-follow-up time interval, laterality of bc, framingham’s 10-year risk score or traditional cad risk factors were detected. increase in cacs related to the senile atherosclerotic process was shown (p < 0.001). conclusions no difference between cacs was noted between bc patients with a history of 3d-crt and the non-bc women without a histo...

The combination of radiotherapy treatments and breast reconstruction, using temporary tissue expanders, generates several concerns due to the presence of a magnetic valve inside the radiation field. The objective of this work is to evaluate a radiotherapy treatment planning for a patient using a tissue expander. Isodose curve maps, obtained using radiochromic films, were compared to the ones ca...