Computer-aided interpretation of electrocardiograms (ECGs) is widespread but many physicians hesitate to rely on the computer, because the advice is presented without information about the confidence of the advice. The purpose of this work was to develop a method to validate the advice of a computer by estimating the error of an artificial neural network output. A total of 1249 ECGs, recorded w...

Smart spaces foster the development of more natural and suitable forms of human-computer interaction taking advantage of customization possibilities offered by the home. The interaction chances of the Digital Home, as a special type of smart space, have a special interest in fields where the acceptance of new technologies is low and restrictive. Homecare is a discipline where this acceptance is...

Abstract I introduce and analyse an anytime version of the Optimally Confident UCB (OCUCB) algorithm designed for minimising the cumulative regret in finitearmed stochastic bandits with subgaussian noise. The new algorithm is simple, intuitive (in hindsight) and comes with the strongest finite-time regret guarantees for a horizon-free algorithm so far. I also show a finite-time lower bound that...

Copy number variations (CNVs) within the human genome have been linked to a diversity of inherited diseases and phenotypic traits. The currently used methodology to measure copy numbers has limited resolution and/or precision, especially for regions with more than 4 copies. Whole genome sequencing (WGS) offers an alternative data source to allow for the detection and characterization of the cop...

Just 5 weeks before his presidency ended, Barack Obama signed the 21st Century Cures Act, a law that will sustain several of his signature biomedical research initiatives, streamline the US drug and medical device approval process, improve the nation’s mental health-care system, and combat the country’s opioid misuse epidemic. The legislation won nearly unanimous approval in both houses of Cong...

BACKGROUND We undertook a needs assessment exercise using questionnaire survey of junior doctors' knowledge and beliefs concerning evidence-based medicine (EBM) and critical literature appraisal, as this is a core competence in postgraduate medical education. METHODS We surveyed 317 junior doctors in various specialities in the UK West Midlands Deanery. Using validated questionnaires we compa...