OBJECTIVE To discuss the implications of expanded genetic carrier screening for preconception purposes based on our practice. METHODS One hundred and forty-three potential gamete donors aged 20-32 years old (µ=24, 127 females and 16 males), signed informed consent forms and were selected according to the REDLARA guidelines. Blood or saliva samples were examined by one of these genetic carrier...

Abstract Lumpfish is used to control sea lice in open net-pen farming of Atlantic salmon, but little known about their nutritional requirements. The aim this study was investigate the effects replacing marine oil (MO) with rapeseed (RO), diets incorporating 50 % plant protein concentrates, on growth, chemical and fatty acid (FA) composition juvenile lumpfish. Four extruded diets, nearly iso-lip...

The study demonstrates whether the Guanchiche of Vinces rivers presents pathogenic bacteria Vibrio type, which can cause many gastrointestinal diseases. fish were obtained directly from sampling sites, and physiological nutritional status was determined through indicators Hepatosomatic Index (IHS), Gonadosomatic (IGS), Condition Factor (CF), microbiological isolation characterization. Values re...

Morphometric relationships, condition factor (CF) and reproductive biology are significant tools in fish stock management, biology, physiology, conservation ecology. Growth strategy of Oreochromis niloticus were studied from 343 specimens collected Lake Shala between January December 2018. Fish samples ranged 7.7 cm to 33.0 total length (TL) 7.80 g 708.21 weight (TW) using gillnets 4, 6, 8, 10,...

Pisin Chen and Yu-Hsiang Lin Department of Physics, National Taiwan University, Taipei 10617, Taiwan Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, Taipei 10617, Taiwan Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Stanford University, Stanford, California 94305, USA Graduate Institute of Astrophysics, National ...

Cystic fibrosis (CF) is the most common lethal inherited disorder and is caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). The CF lung expresses a profound proinflammatory phenotype that appears to be related to a constitutive hypersecretion of interleukin (IL)-8 from airway epithelial cells in response to microbial infection. Since overproduction of IL-8 in CF con...

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is r...

OVERVIEW Cystic fibrosis (CF) is an autosomal recessive disorder that was long considered a terminal illness. Recent genetic discoveries and genomic innovations, however, have transformed the diagnosis, classification, and treatment of this multisystem condition. For affected patients, these breakthroughs offer hope for significantly greater longevity and quality of life and, perhaps, for a fut...