The object of this paper is the identification of Hammerstein systems, which are dynamic systems consisting of a static nonlinearity and a linear time-invariant dynamic system in cascade. We assume that the nonlinear function can be described as a linear combination of p basis functions. We model the system dynamics by means of an np-dimensional vector. This vector, usually referred to as overp...

Extending mutual information (MI), which has been widely used as a similarity measure for rigid registration of multi-modal images, to deformable registration is an active field of research. We propose a self-similarity weighted graph-based implementation of alpha-mutual information (alpha-MI) for nonrigid image registration. The new Self Similarity alpha-MI (SeSaMI) metric takes local structur...

We consider a framework for learning additive classifiers based on regularized empirical risk minimization, where the regularization favors “smooth” functions. We present representations of classifiers for which the optimization problem can be efficiently solved. The first family of such classifiers are derived from a penalized spline formulation due to Eilers and Marx, which is modified to ena...

Caudal regression syndrome (CRS) is a rare congenital disorder in which lumbosacral anomalies are combined with anorectal and urogenital malformations. However, the molecular mechanisms of human CRS are not yet known. Trauma, nutritional problems, toxic agents, and genetics are suggested in the etiology of CRS. To the best of our knowledge, linkage studies of families affected exclusively by CR...

introduction 3d reconstruction of an object from its 2d cross-sections (slices) has many applications in different fields of sciences such as medical physics and biomedical engineering. in order to perform 3d reconstruction, at first, desired boundaries at each slice are detected and then using a correspondence between points of successive slices surface of desired object is reconstructed. mate...

OBJECTIVES/HYPOTHESIS Patients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. STUDY DESIGN Prospective, multicenter, observationa...

There is high prevalence of CKD, defined by reduced GFR, in patients with heart failure. Reduced kidney function is associated with increased morbidity and mortality in this patient population. The cardiorenal syndrome (CRS) involves a bidirectional relationship between the heart and kidneys whereby dysfunction in either may exacerbate the function of the other, but this syndrome has been diffi...

BACKGROUND Chronic rhinosinusitis (CRS) is a common disease in the United States. There are a significant number of patients with CRS who are refractory to standard medical and surgical therapy. Many of these patients also have comorbid allergic rhinitis (AR) and asthma, although the underlying pathophysiology that connects these three conditions remains unclear. OBJECTIVE The goal of this ar...

OBJECTIVE The chemotherapy response score (CRS) system based on histopathological examination has been recently proposed for tubo-ovarian high-grade serous carcinoma (HGSC) to assess response to neoadjuvant chemotherapy (NAC). This study was aimed at validating the CRS system in an external cohort of tubo-ovarian HGSC patients. METHODS This study included 110 tubo-ovarian HGSC patients who un...

Lidar techniques represent a new and fruitful approach in the determination of digital surface models. One of the goals in processing this data is to set up filtering methods allowing to automatically extract the ground and the features (buildings, vegetation,...) superimposed on the terrain itself. In our work the emphasis is posed on the first topic. The method implemented took advantage of t...