نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

2013
X.Q. Chen F. Wang Y.L. Zheng Q.X. Fan D.L. Yue Z.J. Ma

Esophageal cancer (EC) is a common malignancy worldwide. The X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to EC. This study aimed to investigate the effect of XRCC1 genetic variants on susceptibility to EC. A total of 383 EC patients (males: 239, females: 144, mean age: 56.62) and 387 cancer-free controls (males: 251...

2013
Guohua Huang Shaoxi Cai Wei Wang Qing Zhang Aihua Liu

Many studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln, Arg194Trp, Arg280His, -77T>C, and X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphisms with lung cancer risk, but the results remained controversial. Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases...

2014
Wei Wu Lu Liu Zhihua Yin Peng Guan Xuelian Li Baosen Zhou

BACKGROUND Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphic variants on HNC risk. METHODS The PubMed and EMBASE databases were searched for genetic associ...

2013
Zhenqiang Fang Fanglin Chen Xiangwei Wang Shanhong Yi Wei Chen Gang Ye

BACKGROUND A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population. METHODOLOGY/PRINCIPAL...

2014
Zhuo Cao Jia Song Jun Wang Xufeng Guo Shijie Yu Weiguo Dong

BACKGROUND Many reports have shown inconsistent results on the relationship between single nucleotide polymorphisms (SNPs) of X-ray repair cross complementing protein (XRCC1) gene and platinum-based chemotherapeutic efficacy. This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with adva...

Journal: :American journal of epidemiology 2005
Rayjean J Hung Janet Hall Paul Brennan Paolo Boffetta

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to cancer risk. However, epidemiologic findings have been inconsistent. The authors conducted meta-analyses of associations between genes in the base excision repair pathway and cancer risk, focusing on three key genes: 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic end...

Journal: :Annals of hepatology 2013
Samantha Therezinha Almeida Pereira Leite Nathália Marques-Guimarães Júlio César Silva-Oliveira Francisco José Dutra-Souto Raquel Alves-dos-Santos Carmen Lucia Bassi-Branco

INTRODUCTION The progression of hepatic disease in chronic viral hepatitis is accompanied by an increased production of reactive oxygen species (ROS), as well as an accumulation of oxidative DNA damage, which is primarily repaired through base excision repair. XRCC1 (X-ray repair cross complementing protein 1) is one of the most important proteins involved in this repair pathway. The present st...

Journal: :Genetics and molecular research : GMR 2014
L M Dong X Y Zhang H Teng M S Li P Wang

We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies showed n...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005
Giuseppe Matullo Simonetta Guarrera Carlotta Sacerdote Silvia Polidoro Laura Davico Sara Gamberini Margaret Karagas Giovanni Casetta Luigi Rolle Alberto Piazza Paolo Vineis

Bladder cancer is associated with tobacco smoking and occupational exposure. The repair of DNA damage has a key role in protecting the genome from the insults of cancer-causing agents. We analyzed 13 polymorphisms in seven DNA repair genes belonging to different repair pathways [X-ray repair cross-complementing group 1 (XRCC1): 26304C>T, 26651A>G, 28152A>G; xeroderma pigmentosum-D (XPD): 23591A...

Journal: :Nucleic acids research 2004
Jinshui Fan Marit Otterlei Heng-Kuan Wong Alan E Tomkinson David M Wilson

X-ray Repair Cross Complementing 1 (XRCC1) is thought to function as a scaffolding protein in both base excision repair and single-strand break repair (SSBR), since it interacts with several proteins participating in these related pathways and has no known enzymatic activity. Moreover, studies indicate that XRCC1 possesses discrete G1 and S phase-specific functions. To further define the contri...

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