The current study investigates the activation in vivo and regulation of the expression of components of the p38 mitogen-activated protein kinase (MAPK) pathway during gonadotropin-induced formation and development of the rat corpus luteum, employing a sequential PMSG/human CG (hCG) treatment paradigm. We postulated that the p38 MAPK pathway could serve to promote phosphorylation of key substrat...

Introduction: Gonadotropin inhibitory hormone (GnIH) has been known as a key inhibitor of the secretion of gonadotropin releasing hormone (GnRH). Ewe has estrous cycles comprising of follicular and luteal phases. Follicular phase is in turn divided into proestrous and estrous phases. Blood level of LH increases in follicular and decreases in luteal phases. The aim of the present study was to...

Apoptosis is associated with the regression of the corpus luteum (CL) in many species. Since caspases play a central role in apoptosis, we studied several initiators (-2, -8, and -9) and the main effector (-3) caspase in the CL during the estrous cycle of the rat. Two different populations of CL (old and new) were identified on ovaries at estrus and diestrus II (DII). Diminished (P < 0.05) lute...

Follicles from goat and sheep ovaries were characterized for their biochemical and hormonal parameters to investigate the effect of developmental stage of follicles on ovarian steroidogenesis. The follicles were isolated mechanically from follicular and luteal phase ovaries and divided in 6 morphologically different groups (small, medium and large follicular and small, medium and large luteal)....

i read with interest the papers written by peyghambari et al (2008) and niknafs et al   nd   et al   et al   et al   et al   et al   et al   et al   (1994) did not observe any   advantage in the pregnancy rates when adding estrogen+progesterone at luteal phase in patients undergoing ivf (6). in conclusion, the mechanism of luteal phase support in assisted reproduction is complex and a controver...

Modern early rheumatoid arthritis strategies are usually based upon a number of important overarching principles: 1. early diagnosis facilitates early commencement of disease modifying anti-rheumatic therapy; 2. early commencement of treatment reduces the long-term risk of erosive damage and functional decline; 3. composite disease activity measures should be used to quantify global rheumatoid ...

The premenstrual syndrome (PMS) has been proposed to result from excessive exposure to and/or withdrawal of brain opioid activity during the luteal phase. Because hypothalamic opioids are believed to modulate GnRH secretion, in part under the influence of ovarian steroids, we performed longitudinal studies of gonadotropin and ovarian steroid secretion across ovulatory, symptomatic cycles of 17 ...

Background During a normal menstrual cycle, progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic Gnadotropin produced by the corpus luteum. Many questions were raised about the role of follicular fluid aspiration on the granuloma cells at the time of oocyte retrieving during the ART cycles. Authors believes that oocyte retrieval might d...

Background: Adiponectin is an adipocytokines which is secreted from the adipose tissue of human and domestic animals. No information is available regarding the follicular fluid adiponectin concentrations in dairy cows. Therefore, the aim of the present study was to determine the follicular fluid adiponectin concentrations in different-sized follicles in the luteal phase of the estrous cycle in ...