نتایج جستجو برای: combined antineoplastic agents
تعداد نتایج: 722313 فیلتر نتایج به سال:
OBJECTIVES The increase in oral anticancer medications with complex regimens creates a need to assure that patients are taking therapeutic dosages as prescribed. This article reviews the assessment and measurement of adherence to oral antineoplastic agents. DATA SOURCES Research and journal articles from CINAHL and PubMed. CONCLUSION Assessing and measuring adherence to oral antineoplastics...
Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and transport influence the cytotoxic effects of antineoplastic agents in target tumor cells and normal host tissues. This article summarizes several state-of-theart approaches to enhancing the effectiveness and safety of cancer therapy base...
Potential difference across the cell membrane and intracellular activity of the potassium ion in rat liver cells were measured simultaneously using double-barreled potassium ion-selective microelectrodes. Both potential difference across the membrane and K+ activity in liver cells were depressed after treatment with the antineoplastic agents mitomycin C and 5-Flourouracil Dry Syrup, suggesting ...
With the aim of overcoming well-known limitations platinum-based antineoplastic drugs, recent efforts have focused on development new anticancer agents containing metals other than platinum. Among these agents, organopalladium compounds received significant attention due to their generally high stability under physiological conditions. A number shown promising in vitro and vivo antiproliferativ...
Using the in vitro polyclonal blastogenesis test, we identified peritoneal suppressor cells from L1210 leukemia-bearing mice as Ia-negative macrophages. These cells manifested adherence to plastic tubes and sensitivity to silica but not to X-irradiation and treatment with alpha Thy 1.2 or alpha Ia 7 antibody plus complement. The suppressor activity of peritoneal macrophages was detected as earl...
Malignant tumors are potential killers of human life, seriously endangering people’s physical health. As far as the treatment malignant is concerned, there exist many therapeutic methods such surgery, radiotherapy, chemotherapy, among which chemotherapy an important means antitumor therapy. Chemotherapy antineoplastic agents can be divided into alkylating agents, metalloplatinum, plant drugs, a...
The tumor suppressor p53 is mutated in more than 50% of all cancers. Importantly, most clinically useful antineoplastic agents are less potent and efficacious in the context of mutant p53. This situation has prompted a search for agents that cause tumor cell death via molecular mechanisms independent of p53. Our recent investigations with electrophilic prostaglandins enabled us to devise a phar...
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