Tachykinin NK2 receptor antagonists could reduce motility and symptoms during gastrointestinal diseases characterized by local inflammation such as diarrhea or colitis; however, how these conditions change pharmacodynamic and pharmacokinetic characteristics of NK2 receptor antagonists is unknown. We investigated the effect of the peptide NK2 receptor antagonist nepadutant on spontaneous intesti...

Bisphenol A (BPA) accumulates in the maturing gut and liver in utero and is known to alter gut bacterial profiles in offspring. Gut bacterial dysbiosis may contribute to chronic colonic and systemic inflammation. We hypothesized that perinatal BPA exposure-induced intestinal (and liver) inflammation in offspring is due to alterations in the microbiome and colonic metabolome. The 16S rRNA amplic...

Colonic diverticula are outpouchings of mucosa and submucosa through the large intestine wall. Inverted colonic can be confused with adenoma. It is important to differentiate them. Here we report two cases inverted that seem like adenomas.

We read with interest the article ‘Relationship between Colonic Polyp Type and the Neutrophil/Lymphocyte Ratio as a Biomarker’ by Karaman et al (2013). In their study, authors aimed to investigate the neutrophil/lymphocyte ratio (NLR) as a biomarker in distinguishing colonic polyps which are neoplastic or non-neoplastic. Finally, they concluded that despite the low sensitivity and specificity, ...

In the current year colonic drug delivery has gained significance for delivery of drug for the treatment of local diseases related with colon and systemic delivery of therapeutic peptides and proteins. Management could be more effective if it is possible for drug to be directly delivered to colon. This article gives an overview on different approaches utilized for colon specific drug delivery.

Four patients with both carcinoma and Crohn's disease of the colon are reported. Other cases in the world literature are summarized and the relationship between the two diseases is discussed. It is concluded that present evidence does not establish an increased risk of malignancy in colonic Crohn's disease.

TO THE EDITOR: I read with great interest the paper entitled “Relationship between intestinal gas and the development of right colonic diverticula” by Jang et al, which was published in the October 2010 issue of Journal of Neurogastroenterology and Motility. Hydrogen (H2) and methane (CH4) are gases produced in the colon by the breakdown of carbohydrates, due to the action of anaerobic methanog...