Cell surface receptors for laminin may play an important role in tumor migration and metastasis. To evaluate laminin receptor/laminin-binding protein expression in human colon carcinoma, surgical specimens of primary colon cancers and liver metastases were examined by blot hybridization of total RNA with a complementary DNA clone which encodes a Mr 32,000 human laminin-binding protein. The mRNA...

Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

In human colorectal cancer (CRC), TP53 is one of the most important drives genes; it a key regulator apoptosis. The dysfunction gene critical event in development CRC this context, we aimed to evaluate expression Tp53 patients and establish correlation between overexpression p53 with clinical pathological features Colorectal Carcinoma (CRC). This study enrolled 32 carcinoma. was investigated by...

A proliferating cell nuclear antigen (PCNA) was identified with autoantibodies from a patient with systemic lupus erythematosus. Specific antibodies were purified by affinity chromatography in which Novikoff hepatoma nucleolar proteins were conjugated to Sepharose-4B. The purified anti-PCNA antibodies produced bright nucleolar fluorescence in tumor cells as shown by indirect immunofluorescence....

RATIONALE All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been reported elsewhere, which may suggest some linkage between them. PATIENT CONCE...

Background and objective: Claudins are members of a large family of tissue specific adherent proteins which have been suggested as tumor markers. In this study we analyzed the protein expression of claudin 1, 3, 4, 5 and 7, their clinical significance and association with tumor growth pattern in colon carcinoma. Methods: Immunohistochemical staining (IHC) was used to detect the expression of cl...

Colon carcinoma metastases to the thyroid are a rare phenomena. Here we report a case of multiple malignant neoplasms where an incidental diagnosis of colon cancer was made after pathologic evaluation of the thyroid specimen.

Basaloid squamous cell carcinoma (BSCC) of the colon is rarely found proximal to the anal canal. We report a case of an 81-year-old woman who was diagnosed with squamous cell carcinoma (SCC) of the lung without metastasis and BSCC of the sigmoid with differing histologic findings suggesting that these tumors were separate primary neoplasms. SCC of the colon has a dismal prognosis. Surgery is th...

Signet cell carcinomas of the colon are well documented in the adult population, but this cancer incidence is very low in the adolescent population. A 17 year old male child presented with one month of progressive abdominal pain. CT scan of the abdomen showed significant abnormality involving the ascending colon characterized as marked mural thickening. Biopsy results indicated signet ring cell...