The constraint-based analysis has emerged as a useful tool for analysis of biochemical networks. An essential assumption for constraint-based analysis is the formation of a stable steady state. This work investigates dissipation and maintenance of stable states in a simple reversible enzymatic reaction with substrate inhibition. Under mass-action kinetics, the conditions under which the reactio...

The evolutions of practices of seismic slope stability analysis of earth embankment/dam are discussed in this paper. The basic concepts of various methods, salient features, advantages and limitations of each of them are elucidate. Methods for both stability analysis and deformation calculation are presented. Methods for calculation of deformation of post liquefaction stage are also briefed.

Cascading failures have become major threats to network robustness due to their potential catastrophic consequences, where local perturbations can induce global propagation of failures. Unlike failures spreading via direct contacts due to structural interdependencies, overload failures usually propagate through collective interactions among system components. Despite the critical need in develo...

The determination of |Vcb| and |Vub| from semileptonic B decay is reviewed with a critical discussion of the theoretical uncertainties. Future prospects and limitations are also discussed.

Considering the vulnerability of double-layer grid space structures to progressive collapse phenomenon, it is necessary to pay special attention to this phenomenon in the design process. Alternate path method is one of the most appropriate and accepted methods for progressive collapse resistant design of structures. Alternate Path Method permits local failure to occur but provides alternate pat...

BACKGROUND Whereas sudden death, most often associated with cardiovascular collapse, occurs in abusers of the psychostimulant methamphetamine (METH), the underlying mechanism is much less understood. The demonstration that successful resuscitation of an arrested heart depends on maintained functionality of the rostral ventrolateral medulla (RVLM), which is responsible for the maintenance of sta...

The current design method of ultimate capacity beam string structure (BSS) is mainly based on the fixed load ratio (FLR) criterion, seldom considers effect random (RLR) bearing capacity. This paper compared coefficient variation (COV) obtained by RLR criterion with that FLR criterion. It indicates properties have a significant impact COV and should be accounted for. A more realistic limit state...

BACKGROUND Spirometric parameters are the mainstay for diagnosis of COPD, but cannot distinguish airway obstruction from emphysema. We aimed to develop a computer model that quantifies airway collapse on forced expiratory flow-volume loops. We then explored and validated the relationship of airway collapse with computed tomography (CT) diagnosed emphysema in two large independent cohorts. MET...