The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases...

The aim of our study was to evaluate the trypsin-like serine proteases (TLPs) distribution between systemic circulation and pancreatic tissue investigate peculiarities their involvement in extracellular matrix components degradation patients with pathologies electrophoretic analysis methods using. Тhe Khmelnitsky Regional Clinical Hospital aged 28-89 were selected for this study: 20 people chro...

Clostridial collagenases are essential biotechnological tissue dissociation agents owing to their ability cleave different types of collagen. Standardization collagenase-based protocols has been hampered by impurities in products manufactured from Clostridium histolyticum . To enhance the purification process, we produced recombinant collagenase classes G and H, taking advantage Escherichia col...