Professor van der Lely has been barred from entering her laboratory, accessing her data, managing her grants, using her email, and communicating with her students and colleagues at UCL. This is an extraordinary and unjust punishment. The career of a scientist depends on continuous interaction with students, collaborators, funding agencies, and research subjects. This is especially true for a sc...

In this paper, we consider the role that domaindependent control knowledge plays in problem solving systems. Ginsberg and Geddis (Ginsberg & Geddis 1991) h ave claimed that domaindependent control information has no place in declarative systems; instead, they say, such information should be derived from declarative facts about the domain plus domain-independent principles. We dispute their conc...

Introduction Language typologists and cognitive linguists have put the notion of the semantic map to great use over the last decade, particularly in such works as Haspelmath (1997) on indefinite constructions. Croft (2001, 2003) has also developed the notion of conceptual space in his typological and construction grammar work. Thus far, semantic maps have been the result of empirical research i...

Alkaloids, nitrogen-containing secondary plant metabolites, are of major interest to veterinary toxicology because of their occurrence in plant species commonly involved in animal poisoning. Based on epidemiological data, the poisoning of cattle and horses by alkaloid-containing plants is a relatively common occurrence in Europe. Poisoning may occur when the plants contaminate hay or silage or ...

Introduction. Goitre with euthyroid function or with subclinical or mild hyperthyroidism due to thyroid autonomy is common. In anthroposophic medicine various thyroid disorders are treated with Colchicum autumnale (CAU). We examined the effects of CAU in patients with goitre of both functional states. Patients and methods. In an observational study, 24 patients with goitre having suppressed thy...

Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and expresses its target protein, it is immune to colchicine's cytotoxic action and the mechanism of thi...

Colchicine is an alkaloid extracted from autumnal Colchicum plant which is used primarily for its anti-inflammatory therapy effect. Acute intoxication with colchicine is uncommon but often severe and results in multiple visceral organ dysfunctions. The intoxication severity and mortality are directly depending on the ingested dose. The treatment is manly symptomatic. However, the development of...

The origins of anti-rheumatic therapy are very old and mainly related to the use of traditional, sometimes extravagant, treatments, as a part of folk medicine. Spa therapy has long been used for the treatment of rheumatic diseases, as well as, in later times, physical treatments, including electrotherapy. Drug treatment has developed beginning from substances of vegetable origin, such as willow...

We introduce equations for special metrics, and notions of stability for some new types of augmented holomorphic bundles. These new examples include holomorphic extensions, and in this case we prove a Hitchin-Kobayashi correspondence between a certain deformation of the Hermitian-Einstein equations and our definition of stability for an extension. §