It is well known that the production of free radicals is associated with sensory cell death induced by an aminoglycoside. Many researchers have reported that antioxidant reagents protect sensory cells in the inner ear, and coenzyme Q10 (CoQ10) is an antioxidant that is consumed as a health food in many countries. The purpose of this study was to investigate the role of CoQ10 in mammalian vestib...

BACKGROUND The present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (MI) by supplementation with coenzyme Q10 (CoQ10). METHODS In a double-blind, placebo-controlled study, we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule-1 [ICAM-1]), serum concentration ...

Purpose: The solubility of coenzyme Q10 (CoQ10) in water is extremely low, resulting in a low oral bioavailability. In this study, we attempted to improve the low dissolution and bioavailability of CoQ10, by means of the complexation with natural α-, βand γ-cyclodextrins (CyDs) and 2-hydroxypropyl-β-CyD (HP-β-CyD). Methods: The complexation of CoQ10 with CyDs was studied by the solubility metho...

PURPOSE Heart disease is the leading cause of death in the United States. HMG-CoA reductase inhibitors, or statins, are medications at the forefront of the battle against cardiovascular disease. Despite their effectiveness, patient compliance with statins has lagged because of medication cost and adverse effects, namely myopathy. Myopathy is the most common side effect of statin use. The purpos...

coenzyme q10 is a promising   agent for neuroprotection in neurodegenerative   diseases. neuroprotective effects of coenzyme q10 demonstrated in some   neurodegenerative diseases such as parkinson, alzheimer and etc. hippocampus   is home of these diseases. we assayed coenzyme q10 effects on hippocampal   injury model and our hypothesis is that coenzyme q10 has neuroprotective   effects in some...

Statins are among the most widely used drugs in the management of hypercholesterolemia. In addition to inhibiting endogenous cholesterol synthesis, however, statins decrease coenzyme Q10 (CoQ10) synthesis. CoQ10 has been reported to have antioxidant properties, and administration of drugs that decrease CoQ10 synthesis might lead to increased oxidative stress in vivo. Our present study examined ...

Statins have been suggested to protect against Alzheimer's disease (AD). Recently, however, we reported that aged dogs that underwent chronic statin treatment exhibited cognitive deficits compared with age matched controls. In human studies, blood levels of Coenzyme Q10 (CoQ10) decrease with statin use. CoQ10 is important for proper mitochondrial function and is a powerful antioxidant, two impo...

this experiment was conducted to determine the effect of vitamin c (vc) and coenzyme q10 (coq10) onimmunity response of broilers in cold stress condition using 500 male chicks in a completely randomizeddesign with 5 treatments and five replicates. treatments were: positive control (pc, normal conditionsgrowth without antioxidants), negative control (nc, cold stress without antioxidants), cold s...

Coenzyme Q10 (CoQ10) has a wide range of physiological functions and therapeutic value. However, its biomedical application as health product or drug is limited by insolubility low bioavailability. Single-walled carbon nanotubes (SWCNTs) have attracted great interest for agent delivery due to their unique properties. In this study, the pristine SWCNTs are purified with different oxidizing acid,...

The objective of this study was to investigate the effects dietary coenzyme Q10 (CoQ10) sources on antioxidant defense system in blood and liver laying hens. Thirty-six 40-wk old Lohmann Brown hens were randomly assigned three groups based body weight, with four cages layers each. Laying divided into one following groups: control (CON), powdered CoQ10 (PCoQ, 100 mg/kg diet), emulsified (ECoQ, d...