نتایج جستجو برای: cobalamin deficiency
تعداد نتایج: 138422 فیلتر نتایج به سال:
A case of transcobalamin II deficiency with several unique features is described. The clinical presentation was typical. except for a slightly delayed age at presentation and the occurrence of apparent neurologic dysfunction from the beginning. The unusual biochemical feature was a low serum cobalamin level (97 pg/mI). Several cobalaminbinding protein abnormalities coexisted and antedated cobal...
Twelve years of mandatory food fortification with folic acid (FA), during which widespread self-supplementation pushed FA intake even higher, have nurtured questions about risks to persons with cobalamin deficiency but generated little meaningful data until just recently. In 2007 analysis of National Health and Nutrition Examination Study (NHANES) data linked higher folate concentrations with w...
OBJECTIVE There are few studies regarding vitamin B12 deficiency in developing countries. In Brazil, a late diagnosis of vitamin B12 deficiency progressing to severe neurological damage is common. Thus, the aim of the present study was to verify the frequency of vitamin B12 deficiency in two Brazilian populations (elderly and adult participants) and to compare different methods of vitamin B12 d...
Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers through methylation and molecular rearrangement. These functions take place in fatty acid, amino acid and nucleic acid metabolic pathways. The deficiency of vitamin B12 is clinically manifested in the blood and nervous system where the cobalamin plays a key role in cell replication and in fatty acid met...
In adults, the diagnostic utility of total homocysteine (tHcy) determination is well established. Elevated tHcy is a risk factor for adverse pregnancy outcomes [1,2], impaired cognitive function [3] and occlusive arterial and venous disease [4], and the use of tHcy has been recommended in cardiovascular risk assessment [5]. Levels of tHcy are increased in folate and cobalamin deficiencies, and ...
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