We investigate the controlled release of lidocaine hydrochloride from the doped silica-based xerogels. In the xerogel preparation, tetraethoxysilane (TEOS), methyltriethoxysilane (MTES), and propyltriethoxysilane (PTES) are used as precursors, and a nonionic surfactant Igepal CO 720 is used as a dopant. The experimental results suggest that the release of lidocaine hydrochloride can be easily c...

Abstract: Background/Objectives: The objective of the study was to examine feasibility extrusion/ spheronization techniques for formulation castor oil loaded self-emulsifying pellets. also aimed at optimization pellet system with design experiments. Materials and Methods: Various surfactants co-surfactants were tested their ability emulsify oil. proportion components (castor oil, surfactant co-...

Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in self-microemulsifying drug delivery system (SMEDDS) improve the solubility, release rate, and intestinal permeability of drug. Methods: The suitable oil, surfactant, co-surfactant were chosen according solubility study. Utilizing design experiment (DoE) method, pseudo-ternary phase diagram was plott...

Diesel engine is known for its durable operation and capability of utilizing various type fuels, however, dangerous exhaust emissions are emitted from diesel engines. Non-surfactant emulsion fuel a potential to reduce Nitrogen oxides (NOx) Particulate matter (PM) emission compare conventional in engine. In this study, was prepared using mixer as Circulation Non-Surfactant Emulsion Fuel System. ...

Here it is shown that the chemical nature of outer organic surfactant layers, used to stabilize inorganic nanoparticles (NPs), is a key factor controlling solubility in a mixed liquid CO(2)-heptane (10% vol) solvent.

Purpose: Lovastatin is poorly water soluble drug. It should be come into the BCS II drug. So oral bioavailability of lovastatin is less (50%). To develop novel dosage foam of the self-microemulsifying drug delivery systems (SMEDDS) for the lovastatin. Methods: Before the formulation of SMEDDS, solubility study was performed in different exicipients and select exicipients on basis of solubility ...

Molecular dynamics simulations of bilayers in a surfactant/co-surfactant/water system with explicit solvent molecules show formation of topologically distinct gel phases depending upon the bilayer composition. At low temperatures, the bilayers transform from the tilted gel phase, Lβ', to the one dimensional (1D) rippled, Pβ' phase as the surfactant concentration is increased. More interestingly...

Objective: The study aims to develop a Self-nanoemulsifying drug delivery system (SNEDDS) of Quercetin enhance its oral bioavailability.
 Methods: In the present study, was formulated into SNEDDS using various oils, surfactants, and co-surfactants. developed formulations were subjected studies like content analysis, droplet size thermodynamic stability, in vitro release studies.
 Resu...

Desmopressin acetate is a potent synthetic peptide hormone. A more acceptable route of Desmopressin acetate is a potent synthetic peptide hormone. That is administered via parenteral, intranasal, and oral routes. A more acceptable route of administration with potentially good bioavailability could be offered by transdermal delivery. The present work reports on the development of water-in-oil (w...