NFATc1 transcription factor is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis and osteoclastogenesis. We identified a role for calcineurin-NFAT signaling in lymphatic development and patterning. NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial cells (LEC) are specified and as they segreg...

This article considers the two-player composite Nash equilibrium (CNE) problem with a separable non-smooth part, which is known to include the composite saddle-point (CSP) problem as a special case. Due to its two-block structure, this problem can be solved by any algorithm belonging to the block-decomposition hybrid proximal-extragradient (BD-HPE) framework proposed in [13]. The framework cons...

The proximal point mapping is the basis of many optimization techniques for convex functions. By means of variational analysis, the concept of proximal mapping was recently extended to nonconvex functions that are prox-regular and prox-bounded. In such a setting, the proximal point mapping is locally Lipschitz continuous and its set of fixed points coincide with the critical points of the origi...

In this paper we establish criteria for the stability of the proximal mapping Prox φ = (∂φ+∂f)−1 associated to the proper lower semicontinuous convex functions φ and f on a reflexive Banach space X.We prove that, under certain conditions, if the convex functions φn converge in the sense of Mosco to φ and if ξn converges to ξ, then Prox f φn(ξn) converges to Prox f φ(ξ). 1. Preliminaries Let X b...

Density functional theory calculations have been carried out to explore the effect of hydrogen on the oxidation of CO in relation to the preferential oxidation of CO in the presence of excess hydrogen (PROX). A range of gold surfaces have been selected including the (100), stepped (310) surfaces and diatomic rows on the (100) surface. These diatomic rows on Au(100) are very efficient in H-H bon...

Compatible solutes such as glycine betaine and proline betaine are accumulated to exceedingly high intracellular levels by many organisms in response to high osmolarity to offset the loss of cell water. They are excluded from the immediate hydration shell of proteins and thereby stabilize their native structure. Despite their exclusion from protein surfaces, the periplasmic ligand-binding prote...

Schlemm's canal is an important structure of the conventional aqueous humor outflow pathway and is critically involved in regulating the intraocular pressure. In this study, we report a novel finding that prospero homeobox protein 1 (Prox-1), the master control gene for lymphatic development, is expressed in Schlemm's canal. Moreover, we provide a novel in vivo method of visualizing Schlemm's c...

Compatible solutes such as glycine betaine and proline betaine serve as protein stabilizers because of their preferential exclusion from protein surfaces. To use extracellular sources of this class of compounds as osmo-, cryo-, or thermoprotectants, Bacteria and Archaea have developed high affinity uptake systems of the ATP-binding cassette type. These transport systems require periplasmic- or ...