statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...

b a ckground: previous studies have suggested that sex may be a factor influencing basal metabolic rate (bmr) in adults and school age children. however, few data are available about the effects of sex on bmr in pre-school children. in the present study, we investigated whether sex differences contribute to variations in bmr in pre-school age children. m et h o ds : measurements were made on th...

We determined whether the drug efflux protein P-glycoprotein (Pgp) could influence the extent of CYP3A-mediated metabolism of erythromycin, a widely used model substrate for CYP3A. We compared CYP3A metabolism of erythromycin (a Pgp substrate) using the erythromycin breath test in mice proficient and deficient of mdr1 drug transporters. We first injected mdr1(+/+) mice with [(14)C]N-methyl eryt...

The Pereskia are morphologically primitive, leafed members of the Cactaceae. Gas exchange characteristics using a dual isotope porometer to monitor (14)CO(2) and tritiated water uptake, diurnal malic acid fluctuations, phosphoenolpyruvate carboxylase, and malate dehydrogenase activities were examined in two species of the genus Pereskia, Pereskia grandifolia and Pereskia aculeata. Investigation...

The adipocyte-derived hormone leptin inhibits appetite and bone mass accrual. To fulfill these two functions leptin requires the integrity of hypothalamic neurons but not the expression of its receptor, ObRb on these neurons. These results suggested that leptin acts first elsewhere in the brain to mediate these functions. However, this neuroanatomical site of leptin action in the brain remained...

Autism spectrum disorder (hereafter referred to as “ASD”) has broad and heterogeneous clinical manifestations and has been associated with a plethora of possible etiological factors. As such, it has been a challenge to investigate underlying neurobiological mechanisms and to develop effective treatments. Recent studies have increasingly implicated mitochondrial dysfunction as a cause of ASD. Mi...