We demonstrate a newly-developed magneto-fluorescent carbon nanotube (CNT) mediated siRNA (CNT-siRNA) delivery system, which significantly silences our target of interest, gastrin-releasing peptide receptor (GRP-R), in neuroblastoma. CNT-siGRP-R resulted in a 50% silencing efficiency and a sustained efficacy of 9 days for one-time siRNA treatment in vitro, whereas siRNA delivered by the commerc...

After clarifying the formation mechanism of a typical metal glycolate precipitate, Ti glycolate, in a polyol-mediated synthesis using acetone as a precipitation medium, we describe a simple template-free approach based on an ethylene glycol-mediated synthesis to fabricate mesoporous metal oxide coated-nanocarbon hybrid materials including TiO₂ coated-carbon nanotube (CNT), SnO₂ coated-CNT, Cu₂O...

Functionalization of carbon nanotube (CNT) was performed, during preparation of Fischer–Tropsch synthesis (FTS) via cobalt nanocatalysts, to modify the surface properties of CNT support. Common and functionalized CNT supported cobalt nanocatalysts were prepared using impregnation wetness method with cobalt loading of 15 wt.%. The catalysts were characterized by Brunauer–Emmett–Teller (BET), Fou...

Oxygen plasma treatment is introduced herein as a novel post-growth fabrication technique to engineer the macroscopic morphology of hollow carbon nanotube (CNT) pillars. Current fabrication techniques for patterned vertically-aligned CNTs only allow for the production of extruded structures with constant cross-sectional area. Oxygen plasma treatment is utilized to rectify this limitation by int...

We have fabricated suspended carbon nanotube (CNT) devices specifically designed for biological sensing applications. We use 6-inch-wafer processes to maximize yield. Our fabrication process produces suspended CNT with clean surfaces and minimal environ mental noise. The electrode layout is compatible with a microfluidic system for delivering liquids and biological molecules to the sensor. We r...

The application of plasma-enhanced chemical vapour deposition (PECVD) in the production and modification of carbon nanotubes (CNTs) will be reviewed. The challenges of PECVD methods to grow CNTs include low temperature synthesis, ion bombardment effects and directional growth of CNT within the plasma sheath. New strategies have been developed for low temperature synthesis of single-walled CNTs ...

Purpose: Stimulation of toll-like receptor-9 (TLR9) by CpG oligodeoxynucleotides (CpG) has been shown to counteract the immunosuppressive microenvironment and to inhibit tumor growth in glioma models. Because TLR9 is located intracellularly, we hypothesized that methods that enhance its internalization may also potentiate its immunostimulatory response. The goal of this study was to evaluate ca...

A novel 3D carbon nanotube (CNT) microelectrode was developed through direct growth of CNTs on a gold pin-shaped 3D microelectrode at a low temperature (400 °C) for applications in neural and cardiac recording. With an electroplated Ni catalyst layer covering the entire surface of the pin-shaped structure, CNTs were synthesized on a 3D microelectrode by catalytic thermal chemical vapor depositi...

We report a simple stepped growth process for the synthesis of carbon nanotubes (CNTs) having excellent field emission properties. CNT growth was interrupted in the process. During the interruption, the catalyst was re-activated in-situ. This resulted in enhanced growth of the CNTs after the interruption and a film of CNTs re-grew on top of an existing CNT film at much higher rates. The enhance...