Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular levels in the immature brain, which appears more vulnerable to injury than in the adult one, we co...

Brain-specific homing and direct interactions with the neural substance are prominent hypotheses for brain metastasis formation and a modern manifestation of Paget's "seed and soil" concept. However, there is little direct evidence for this "neurotropic" growth in vivo. In contrast, many experimental studies have anecdotally noted the propensity of metastatic cells to grow along the exterior of...

Abstract Blood-brain barrier (BBB) permeable agents effective against recurrent, chemotherapy-resistant central nervous system (CNS) tumors are urgently needed, particularly in Glioblastoma multiforme (GBM) and atypical teratoid/rhabdoid (ATRT). These represent extremely aggressive lethal types of CNS malignancies. LP-184 is a next-generation acylfulvene class drug candidate has received FDA or...

background: in this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to mahak pediatric cancer treatment and research center (one of the main national referral centers for childhood malignancies in iran) for treatment. materials and methods: this cohort (simple sampling) study consisted of 198 children less than 15 year old with cns tumor refer...

crush preparation cytology technique was used during the operative procedure for the diagnosis of 199 cns tumors. this technique is simple, easy to perform, rapid, and inexpensive. the cytomorphologic findings were excellent and helped achieve a rapid and correct diagnosis. this technique was used on the tiny, small specimens which were not suitable for frozen sectioning. the results were compa...

This paper outlines the clinical doctoral research plan (funded by HEE/NIHR Integrated Clinical Academic Programme) to engage the wide range of people who use alternative and augmentative communication (AAC) to understand the perspectives of users in order to develop a Patient Reported Outcome Measure (PROM) to evaluate equipment and services.

we present 16 years old girl with primary breast lymphoma involving the both breasts simultaneously and co-incidence of central nervous system (cns) involvement which originated from the breast, in addition to evidence of lymphoma in multi-organ such as skin, mediastinum and some abdominal viscera. bilaterality has been observed in some series, but reports are few and series are often very smal...